Randall, T.S. and Moores, Carolyn A. and Stephenson, F.A. (2013) Delineation of the TRAK binding regions of the kinesin-1 motor proteins. FEBS Letters 587 (23), pp. 3763-3769. ISSN 1873-3468.
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Abstract
Understanding specific cargo distribution in differentiated cells is a major challenge. Trafficking kinesin proteins (TRAKs) are kinesin adaptors. They bind the cargo binding domain of kinesin-1 motor proteins forming a link between the motor and their cargoes. To refine the TRAK1/2 binding sites within the kinesin-1 cargo domain, rationally designed C-terminal truncations of KIF5A and KIF5C were generated and their co-association with TRAK1/2 determined by quantitative co-immunoprecipitations following co-expression in mammalian cells. Three contributory regions forming the TRAK2 binding site within KIF5A and KIF5C cargo binding domains were delineated. Differences were found between TRAK1/2 with respect to association with KIF5A.
Metadata
| Item Type: | Article |
|---|---|
| Keyword(s) / Subject(s): | kinesin, kinesin adaptor proteins, TRAK, motor proteins, intracellular transport, mitochondrial trafficking |
| School: | Birkbeck Faculties and Schools > Faculty of Science > School of Natural Sciences |
| Research Centres and Institutes: | Structural Molecular Biology, Institute of (ISMB) |
| Depositing User: | Carolyn Moores |
| Date Deposited: | 23 Jun 2016 13:23 |
| Last Modified: | 02 Aug 2023 17:25 |
| URI: | https://eprints.bbk.ac.uk/id/eprint/15610 |
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