Magoulas, George D. and Papaioannou, D. and Papadimou, E. and Drainas, D. (2009) Preparation of spermine conjugates with acidic retinoids with potent ribonuclease P inhibitory activity. European Journal of Medicinal Chemistry 44 (6), pp. 2689-2695. ISSN 0223-5234.
Abstract
Novel mono- and diacylated spermines, readily obtained using isolable succinimidyl active esters of acidic retinoids for the selective acylation of free spermine or in situ activated acidic retinoids for acylating selectively protected spermine followed by deprotection, were shown to inhibit the ribozyme ribonuclease P more strongly than the parent retinoids.
Metadata
| Item Type: | Article |
|---|---|
| Keyword(s) / Subject(s): | ATRA, all-trans-retinoic acid, ACI, acitretin, Ch, cyclohexyl, DCM, dichloromethane, SPM, spermine, RAR, retinoic acid receptor, RXR, retinoid X receptor, RNase P, ribonuclease P, RT, room temperature, TFA, trifluoroacetic acid |
| School: | Birkbeck Faculties and Schools > Faculty of Science > School of Computing and Mathematical Sciences |
| Research Centres and Institutes: | Birkbeck Knowledge Lab |
| Depositing User: | Administrator |
| Date Deposited: | 04 Feb 2011 15:37 |
| Last Modified: | 09 Aug 2023 12:30 |
| URI: | https://eprints.bbk.ac.uk/id/eprint/1879 |
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