Protein-injection machines in bacteria

Galán, J.E. and Waksman, Gabriel (2018) Protein-injection machines in bacteria. Cell 172 (6), pp. 1306-1318. ISSN 0092-8674.

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Official URL: https://doi.org/10.1016/j.cell.2018.01.034

Abstract

Many bacteria have evolved specialized nanomachines with the remarkable ability to inject multiple bacterially encoded effector proteins into eukaryotic or prokaryotic cells. Known as type III, type IV, and type VI secretion systems, these machines play a central role in the pathogenic or symbiotic interactions between multiple bacteria and their eukaryotic hosts, or in the establishment of bacterial communities in a diversity of environments. Here we focus on recent progress elucidating the structure and assembly pathways of these machines. As many of the interactions shaped by these machines are of medical importance, they provide an opportunity to develop novel therapeutic approaches to combat important human diseases.

Metadata

Item Type:	Article
School:	Birkbeck Faculties and Schools > Faculty of Science > School of Natural Sciences
Depositing User:	Administrator
Date Deposited:	11 Apr 2018 17:52
Last Modified:	02 Aug 2023 17:41
URI:	https://eprints.bbk.ac.uk/id/eprint/22106

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