Bullock, Joshua and Thalassinos, Konstantinos and Topf, Maya (2018) Jwalk and MNXL web server: model validation using restraints from Crosslinking Mass Spectrometry. Bioinformatics 34 (20), pp. 3584-3585. ISSN 1367-4803.
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Abstract
Motivation: Crosslinking Mass Spectrometry generates restraints that can be used to model proteins and protein complexes. Previously, we have developed two methods, to help users achieve better modelling performance from their crosslinking restraints: Jwalk, to estimate solvent accessible distances between crosslinked residues and MNXL, to assess the quality of the models based on these distances. Results: Here we present the Jwalk and MNXL webservers, which streamline the process of validating monomeric protein models using restraints from crosslinks. We demonstrate this by using the MNXL server to filter models made of varying quality, selecting the most native-like. Availability: The webserver and source code are freely available from jwalk.ismb.lon.ac.uk and mnxl.ismb.lon.ac.uk.
Metadata
| Item Type: | Article |
|---|---|
| School: | Birkbeck Faculties and Schools > Faculty of Science > School of Natural Sciences |
| Depositing User: | Administrator |
| Date Deposited: | 09 May 2018 18:51 |
| Last Modified: | 02 Aug 2023 17:41 |
| URI: | https://eprints.bbk.ac.uk/id/eprint/22356 |
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