Ruiz-Perez, L. and Hurley, C. and Tomas, Salvador and Battaglia, G. (2018) Separating extreme pH gradients using Amphiphilic Copolymer Membranes. ChemPhysChem 19 (16), pp. 1987-1989. ISSN 1439-7641.
This is the latest version of this item.
|
Text
AuthorManus.pdf - Author's Accepted Manuscript Download (628kB) | Preview |
Abstract
Polymeric vesicles, also called polymersomes, are highly efficient biomimetic systems. They can generate compartmentalized volumes at the nanoscale supported by synthetic amphiphilic membranes that closely mimic their biological counterparts. Membrane permeability and the ability to separate extreme pH gradients is a crucial condition a successful biomimetic system must meet. We show that polymersomes formed by non-ionic polybutadiene-b-polyethylene oxide (PBd-b-PEO) amphiphilic block copolymers engineer robust and stable membranes that are able to sustain pH gradients of 10 for a minimum of eight days. The cells’ endo-lysomal compartments separate gradients between three and one, while we generated a pH gradient of threefold as great. This feature clearly is of great importance for applications as nanoreactors and drug-delivery systems where separating different aqueous volumes at the nanoscale level is an essential requirement.
Metadata
| Item Type: | Article |
|---|---|
| Additional Information: | This is the peer reviewed version of the article, which has been published in final form at the link above. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving. |
| School: | Birkbeck Faculties and Schools > Faculty of Science > School of Natural Sciences |
| Depositing User: | Salvador Tomas |
| Date Deposited: | 09 Jul 2018 10:50 |
| Last Modified: | 02 Aug 2023 17:42 |
| URI: | https://eprints.bbk.ac.uk/id/eprint/23029 |
Available Versions of this Item
-
Separating Extreme pH Gradients Using Amphiphilic
Copolymer Membranes. (deposited UNSPECIFIED)
- Separating extreme pH gradients using Amphiphilic Copolymer Membranes. (deposited 09 Jul 2018 10:50) [Currently Displayed]
Statistics
Additional statistics are available via IRStats2.
Archive Staff Only (login required)
