Roberts, Anthony (2018) Emerging mechanisms of dynein transport in the cytoplasm versus the cilium. Biochemical Society Transactions , ISSN 0300-5127.
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Abstract
Two classes of dynein power long-distance cargo transport in different cellular contexts. Cytoplasmic dynein-1 is responsible for the majority of transport toward microtubule minus ends in the cell interior. Dynein-2, also known as intraflagellar transport dynein, moves cargoes along the axoneme of eukaryotic cilia and flagella. Both dyneins operate as large ATP-driven motor complexes, whose dysfunction is associated with a group of human disorders. But how similar are their mechanisms of action and regulation? To examine this question, this review focuses on recent advances in dynein-1 and -2 research, and probes to what extent the emerging principles of dynein-1 transport could apply to or differ from those of the less well-understood dynein-2 mechanoenzyme.
Metadata
| Item Type: | Article |
|---|---|
| Keyword(s) / Subject(s): | cilia, dynein, intraflagellar transport, kinesin, microtubule |
| School: | Birkbeck Faculties and Schools > Faculty of Science > School of Natural Sciences |
| Research Centres and Institutes: | Structural Molecular Biology, Institute of (ISMB) |
| Depositing User: | Anthony Roberts |
| Date Deposited: | 01 Aug 2018 13:52 |
| Last Modified: | 02 Aug 2023 17:43 |
| URI: | https://eprints.bbk.ac.uk/id/eprint/23396 |
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