BIROn - Birkbeck Institutional Research Online

    FGF binding and FGF receptor activation by synthetic heparan-derived di- and trisaccharides

    Ornitz, D. and Herr, A. and Nillson, M. and Westman, J. and Svahn, C.-M. and Waksman, Gabriel (1995) FGF binding and FGF receptor activation by synthetic heparan-derived di- and trisaccharides. Science 268 (5209), pp. 432-436. ISSN 0036-8075.

    Full text not available from this repository.

    Abstract

    Fibroblast growth factors (FGFs) require a polysaccharide cofactor, heparin or heparan sulfate (HS), for receptor binding and activation. To probe the molecular mechanism by which heparin or HS (heparin/HS) activates FGF, small nonsulfated oligosaccharides found within heparin/HS were assayed for activity. These synthetic and isomerically pure compounds can activate the FGF signaling pathway. The crystal structures of complexes between FGF and these heparin/HS oligosaccharides reveal several binding sites on FGF and constrain possible mechanisms by which heparin/HS can activate the FGF receptor. These studies establish a framework for the molecular design of compounds capable of modulating FGF activity.

    Metadata

    Item Type: Article
    School: Birkbeck Faculties and Schools > Faculty of Science > School of Natural Sciences
    Depositing User: Sarah Hall
    Date Deposited: 29 Apr 2019 15:37
    Last Modified: 02 Aug 2023 17:51
    URI: https://eprints.bbk.ac.uk/id/eprint/27351

    Statistics

    Activity Overview
    6 month trend
    0Downloads
    6 month trend
    359Hits

    Additional statistics are available via IRStats2.

    Archive Staff Only (login required)

    Edit/View Item
    Edit/View Item