New rapamycin derivatives by precursor-directed biosynthesis

Lowden, Philip and Böhm, G.A. and Metcalfe, S. and Staunton, J. and Leadlay, P.F. (2004) New rapamycin derivatives by precursor-directed biosynthesis. ChemBioChem 5 (4), pp. 535-538. ISSN 1439-4227.

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Official URL: https://doi.org/10.1002/cbic.200300758

Abstract

Possible new immunosuppressants through biosynthesis: Derivatives of the immunosuppressant rapamycin, such as analogue 3, are obtained by feeding simple carboxylic acids to the rapamycin‐producing organism. Incorporation of these alternative starter units appears to be preceded by their specific hydroxylation.

Metadata

Item Type:	Article
School:	Birkbeck Faculties and Schools > Faculty of Science > School of Natural Sciences
Depositing User:	Sarah Hall
Date Deposited:	07 May 2019 15:23
Last Modified:	02 Aug 2023 17:51
URI:	https://eprints.bbk.ac.uk/id/eprint/27430

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