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    New rapamycin derivatives by precursor-directed biosynthesis

    Lowden, Philip and Böhm, G.A. and Metcalfe, S. and Staunton, J. and Leadlay, P.F. (2004) New rapamycin derivatives by precursor-directed biosynthesis. ChemBioChem 5 (4), pp. 535-538. ISSN 1439-4227.

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    Possible new immunosuppressants through biosynthesis: Derivatives of the immunosuppressant rapamycin, such as analogue 3, are obtained by feeding simple carboxylic acids to the rapamycin‐producing organism. Incorporation of these alternative starter units appears to be preceded by their specific hydroxylation.


    Item Type: Article
    School: Birkbeck Faculties and Schools > Faculty of Science > School of Natural Sciences
    Depositing User: Sarah Hall
    Date Deposited: 07 May 2019 15:23
    Last Modified: 02 Aug 2023 17:51


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