Thomas, A.M. and Brolih, S. and McGouran, J. and El-Sagheer, A.H. and Ptchelkine, D. and Jones, M. and McDonald, Neil Q. and McHugh, P.J. and Brown, T. (2019) Optimised oligonucleotide substrates to assay XPF ERCC1 nuclease activity for the discovery of DNA repair inhibitors. Chemical Communications 55 , pp. 11671-11674. ISSN 1359-7345.
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Abstract
We report the design and optimisation of novel oligonucleotide substrates for a sensitive fluorescence assay for high-throughput screening and functional studies of the DNA repair enzyme, XPF-ERCC1, with a view to accelerating inhibitor and drug discovery
Metadata
| Item Type: | Article |
|---|---|
| School: | Birkbeck Faculties and Schools > Faculty of Science > School of Natural Sciences |
| Research Centres and Institutes: | Structural Molecular Biology, Institute of (ISMB) |
| Depositing User: | Neil Mcdonald |
| Date Deposited: | 16 Sep 2019 08:06 |
| Last Modified: | 02 Aug 2023 17:54 |
| URI: | https://eprints.bbk.ac.uk/id/eprint/28891 |
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