Bates, E. and Wilson, S.M. and Saygin, A.P. and Dick, Frederic and Sereno, M.I. and Knight, R.T. and Dronkers, N.F. (2003) Voxel-based lesion: symptom mapping. Nature Neuroscience 6 (5), pp. 448-450. ISSN 1546-1726.
Abstract
For more than a century, lesion–symptom mapping studies have yielded valuable insights into the relationships between brain and behavior, but newer imaging techniques have surpassed lesion analysis in examining functional networks. Here we used a new method—voxel-based lesion–symptom mapping (VLSM)—to analyze the relationship between tissue damage and behavior on a voxel-by-voxel basis, as in functional neuroimaging. We applied VLSM to measures of speech fluency and language comprehension in 101 left-hemisphere-damaged aphasic patients: the VLSM maps for these measures confirm the anticipated contrast between anterior and posterior areas, and they also indicate that interacting regions facilitate fluency and auditory comprehension, in agreement with findings from modern brain imaging.
Metadata
| Item Type: | Article |
|---|---|
| School: | Birkbeck Faculties and Schools > Faculty of Science > School of Psychological Sciences |
| Depositing User: | Sarah Hall |
| Date Deposited: | 18 Nov 2019 14:26 |
| Last Modified: | 02 Aug 2023 17:55 |
| URI: | https://eprints.bbk.ac.uk/id/eprint/29996 |
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