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    Voxel-based lesion: symptom mapping

    Bates, E. and Wilson, S.M. and Saygin, A.P. and Dick, Frederic and Sereno, M.I. and Knight, R.T. and Dronkers, N.F. (2003) Voxel-based lesion: symptom mapping. Nature Neuroscience 6 (5), pp. 448-450. ISSN 1546-1726.

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    For more than a century, lesion–symptom mapping studies have yielded valuable insights into the relationships between brain and behavior, but newer imaging techniques have surpassed lesion analysis in examining functional networks. Here we used a new method—voxel-based lesion–symptom mapping (VLSM)—to analyze the relationship between tissue damage and behavior on a voxel-by-voxel basis, as in functional neuroimaging. We applied VLSM to measures of speech fluency and language comprehension in 101 left-hemisphere-damaged aphasic patients: the VLSM maps for these measures confirm the anticipated contrast between anterior and posterior areas, and they also indicate that interacting regions facilitate fluency and auditory comprehension, in agreement with findings from modern brain imaging.


    Item Type: Article
    School: Birkbeck Faculties and Schools > Faculty of Science > School of Psychological Sciences
    Depositing User: Sarah Hall
    Date Deposited: 18 Nov 2019 14:26
    Last Modified: 02 Aug 2023 17:55


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