Gupta, Antima and Kaul, Akshay and Tsolaki, A.G. and Kishore, U. and Bhakta, Sanjib (2012) Mycobacterium tuberculosis: immune evasion, latency and reactivation. Immunobiology 217 (3), pp. 363-374. ISSN 0171-2985.
Abstract
One-third of the global human population harbours Mycobacterium tuberculosis in dormant form. This dormant or latent infection presents a major challenge for global efforts to eradicate tuberculosis, because it is a vast reservoir of potential reactivation and transmission. This article explains how the pathogen evades the host immune response to establish a latent infection, and how it emerges from a state of latency to cause reactivation disease. This review highlights the key factors responsible for immune evasion and reactivation. It concludes by identifying interesting candidates for drug or vaccine development, as well as identifying unresolved questions for the future research.
Metadata
| Item Type: | Article |
|---|---|
| Keyword(s) / Subject(s): | Immune evasion, immune response, latency, Mycobacterium tuberculosis, reactivation |
| School: | Birkbeck Faculties and Schools > Faculty of Science > School of Natural Sciences |
| Research Centres and Institutes: | Structural Molecular Biology, Institute of (ISMB) |
| Depositing User: | Administrator |
| Date Deposited: | 19 Jul 2011 08:03 |
| Last Modified: | 02 Aug 2023 16:55 |
| URI: | https://eprints.bbk.ac.uk/id/eprint/3810 |
Statistics
Additional statistics are available via IRStats2.
Archive Staff Only (login required)
