Clinical and translational implications of new understanding of a developmental sub structure for autism

Constantino, J. and Charman, T. and Jones, Emily J.H. (2021) Clinical and translational implications of new understanding of a developmental sub structure for autism. Annual Review of Clinical Psychology 17 , pp. 365-389. ISSN 1548-5943.

Abstract

A vast share of the population attributable risk for autism relates to inherited polygenic risk. A growing number of recent studies have indicated that inherited susceptibility may operate through a finite number of early developmental liabilities which, in various permutations and combinations, jointly predict familial recurrence of the convergent syndrome of social-communicative disability that defines the condition. Here we synthesize this body of research to derive evidence for a novel developmental sub structure for autism, which has profound implications for ongoing discovery efforts to elucidate its neurobiological causes, and to inform future clinical and biomarker studies, early intervention, and personalized approaches to therapy.

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