Parker, P.J. and Brown, S.J. and Calleja, V. and Chakravarty, P. and Cobbaut, M. and Linch, M. and Marshall, J.J.T. and Martini, S. and McDonald, Neil Q. and Soliman, T. and Watson, L. (2021) Equivocal, explicit and emergent actions of PKC isoforms in Cancer. Nature Reviews Cancer 21 , pp. 51-63. ISSN 1474-175X.
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Abstract
The maturing mutational landscape of cancer genomes, the development and application of clinical interventions, and evolving insights into tumour- associated functions, reveal unexpected features of the protein kinase C (PKC) family of serine/threonine protein kinases. These advances include recent work showing gain or loss-of-function mutations relating to driver or bystander roles, how conformational constraints and plasticity impact this class of proteins and how emergent cancer associated properties may offer opportunities for intervention. The profound impact of the tumour microenvironment, reflected in the efficacy of immune checkpoint interventions, further prompts to incorporate PKC family actions and interventions in this eco-system, informed by insights into the control of stromal and immune cell functions. Drugging PKC isoforms has offered much promise, but the when and how is not obvious.
Metadata
| Item Type: | Article |
|---|---|
| School: | Birkbeck Faculties and Schools > Faculty of Science > School of Natural Sciences |
| Research Centres and Institutes: | Structural Molecular Biology, Institute of (ISMB) |
| Depositing User: | Neil Mcdonald |
| Date Deposited: | 29 Oct 2020 10:25 |
| Last Modified: | 02 Aug 2023 18:04 |
| URI: | https://eprints.bbk.ac.uk/id/eprint/41063 |
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