Cragnolini, Tristan and Sahota, Harpal and Joseph, Agnel Praveen and Sweeney, Aaron and Malhotra, Sony and Vasishtan, D. and Topf, Maya (2021) TEMPy2: a Python library with improved 3D electron microscopy density-fitting and validation workflows. Acta Crystallographica Section D: Structural Biology 77 (1), pp. 41-47. ISSN 2059-7983.
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Abstract
Structural determination of molecular complexes by cryo-EM requires large, often complex processing of the image data that are initially obtained. Here, TEMPy2, an update of the TEMPy package to process, optimize and assess cryo-EM maps and the structures fitted to them, is described. New optimization routines, comprehensive automated checks and workflows to perform these tasks are described.
Metadata
| Item Type: | Article |
|---|---|
| Keyword(s) / Subject(s): | three-dimensional electron microscopy, model fitting, validation, fitting scores, model assessment, macromolecular complexes, TEMPy2. |
| School: | Birkbeck Faculties and Schools > Faculty of Science > School of Natural Sciences |
| Depositing User: | Administrator |
| Date Deposited: | 15 Jan 2021 13:01 |
| Last Modified: | 02 Aug 2023 18:07 |
| URI: | https://eprints.bbk.ac.uk/id/eprint/42601 |
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