Early differences in auditory processing relate to Autism Spectrum Disorder traits in infants with Neurofribramatosis Type I

Begum Ali, Jannath and Kolesnik-Taylor, A. and Quiroz, I. and Mason, Luke and Garg, S. and Green, J. and Johnson, Mark H. and Jones, Emily J.H. (2021) Early differences in auditory processing relate to Autism Spectrum Disorder traits in infants with Neurofribramatosis Type I. Journal of Neurodevelopmental Disorders 13 , ISSN 1866-1955.

Abstract

Background: sensory modulation difficulties are common in children with conditions such as Autism Spectrum Disorder (ASD), and could contribute to other social and non-social symptoms. Positing a causal role for sensory processing differences requires observing atypicalsensory reactivity prior to the emergence of other symptoms, which can be achieved through prospective studies. Methods: in this longitudinalstudy, we examined auditory repetition suppression and change detection at 5 and 10-months ininfants with and without Neurofibromatosis Type 1 (NF1), a condition associated with higher likelihood of developing ASD. Results: in typically developing infants, suppression to vowel repetition and enhancedresponses to vowel/pitchchangedecreased with ageoverposterior regions, becoming more frontally-specific; age-related change was diminished in the NF1group. Whilst both groups detected changes in vowel and pitch, the NF1group were largely slower to show a differentiated neural response. Auditory responses did not relate to later language but were related to later ASD traits. Conclusions: these findings represent the first demonstration of atypical brain responses to soundsin infants with NF1, and suggests they may relate to the likelihood of later ASD.

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