BIROn - Birkbeck Institutional Research Online

    The PDB and protein homeostasis: from chaperones to degradation and disaggregase machines

    Saibil, Helen R. (2021) The PDB and protein homeostasis: from chaperones to degradation and disaggregase machines. Journal of Biological Chemistry 296 , p. 100744. ISSN 0021-9258.

    [img]
    Preview
    Text
    44469.pdf - Published Version of Record
    Available under License Creative Commons Attribution.

    Download (4MB) | Preview

    Abstract

    This review contains a personal account of the role played by the PDB in the development of the field of molecular chaperones and protein homeostasis, from the viewpoint of someone who experienced the concurrent advances in the structural biology, electron microscopy, and chaperone fields. The emphasis is on some key structures, including those of Hsp70, GroEL, Hsp90, and small heat shock proteins, that were determined as the molecular chaperone concept and systems for protein quality control were emerging. These structures were pivotal in demonstrating how seemingly nonspecific chaperones could assist the specific folding pathways of a variety of substrates. Moreover, they have provided mechanistic insights into the ATPase machinery of complexes such as GroEL/GroES that promote unfolding and folding and the disaggregases that extract polypeptides from large aggregates and disassemble amyloid fibers. The PDB has provided a framework for the current success in curating, evaluating, and distributing structural biology data, through both the PDB and the EMDB.

    Metadata

    Item Type: Article
    Keyword(s) / Subject(s): chaperone, protein folding, protein misfolding, protein aggregation, proteostasis, GroEL, DnaK, ATPases associated with diverse cellular activities (AAA), heat shock protein 90 (Hsp90)
    School: Birkbeck Faculties and Schools > Faculty of Science > School of Natural Sciences
    Depositing User: Administrator
    Date Deposited: 27 May 2021 13:46
    Last Modified: 02 Aug 2023 18:10
    URI: https://eprints.bbk.ac.uk/id/eprint/44469

    Statistics

    Activity Overview
    6 month trend
    60Downloads
    6 month trend
    87Hits

    Additional statistics are available via IRStats2.

    Archive Staff Only (login required)

    Edit/View Item Edit/View Item