Ronald, Angelica and Butcher, L.M. and Docherty, S.J. and Davis, O.S.P. and Schalkwyk, L.C. and Craig, I.W. and Plomin, R. (2010) A genome-wide association study of social and non-social autistic-like traits in the general population using pooled DNA, 500 K SNP microarrays and both community and diagnosed autism replication samples. Behavior Genetics 40 (1), pp. 31-45. ISSN 0001-8244.
Abstract
Two separate genome-wide association studies were conducted to identify single nucleotide polymorphisms (SNPs) associated with social and nonsocial autistic-like traits. We predicted that we would find SNPs associated with social and non-social autistic-like traits and that different SNPs would be associated with social and nonsocial. In Stage 1, each study screened for allele frequency differences in ~430,000 autosomal SNPs using pooled DNA on microarrays in high-scoring versus low-scoring boys from a general population sample (N = ~400/group). In Stage 2, 22 and 20 SNPs in the social and non-social studies, respectively, were tested for QTL association by individually genotyping an independent community sample of 1,400 boys. One SNP (rs11894053) was nominally associated (P < .05, uncorrected for multiple testing) with social autistic-like traits. When the sample was increased by adding females, 2 additional SNPs were nominally significant (P < .05). These 3 SNPs, however, showed no significant association in transmission disequilibrium analyses of diagnosed ASD families.
Metadata
| Item Type: | Article |
|---|---|
| Keyword(s) / Subject(s): | autistic traits, genome-wide association, autism, microarrays, heritability, pooling |
| School: | Birkbeck Faculties and Schools > Faculty of Science > School of Psychological Sciences |
| Research Centres and Institutes: | Brain and Cognitive Development, Centre for (CBCD) |
| Depositing User: | Sarah Hall |
| Date Deposited: | 22 Jun 2012 07:10 |
| Last Modified: | 02 Aug 2023 16:57 |
| URI: | https://eprints.bbk.ac.uk/id/eprint/4769 |
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