Chauviac, Francois-Xavier and Robertson, Giles and Quay, Doris H.X. and Bagneris, Claire and Dumas, C. and Henderson, B. and Ward, J. and Keep, Nicholas H. and Cohen-Gonsaud, Martin (2014) RpfC (Rv1884) atomic structure shows high structural conservation within the resuscitation promoting factor catalytic domain. Acta Crystallographica Section F: Structural Biology Communications F70 (8), pp. 1022-1026. ISSN 1744-3091.
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Abstract
We report the first structure of the catalytic domain of RpfC (Rv1884), one of theresuscitation-promoting factors (RPFs) from Mycobacterium tuberculosis. The structure was solved using molecular replacement, once the space group had been correctly identified as twinned P21 rather than the apparent C2221 by searching for anomalous scattering sites in P1. The structure displays a very high degree of structural conservation with the structures of the catalytic domains of RpfB (Rv1009) and RpfE (Rv2450) already published. This structural conservation highlights the importance of the versatile domain composition of the RPF family.
Metadata
| Item Type: | Article |
|---|---|
| Keyword(s) / Subject(s): | Resuscitation Promoting Factor, Peptidoglycan, X-ray Crystallography |
| School: | Birkbeck Faculties and Schools > Faculty of Science > School of Natural Sciences |
| Research Centres and Institutes: | Structural Molecular Biology, Institute of (ISMB) |
| Depositing User: | Administrator |
| Date Deposited: | 16 Jun 2014 11:21 |
| Last Modified: | 02 Aug 2023 17:11 |
| URI: | https://eprints.bbk.ac.uk/id/eprint/9949 |
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