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July 2010
Briggs, D.C. and Smedley, J.G. and McClane, B.A. and Basak, Ajit K. (2010) Crystallization and preliminary crystallographic analysis of theClostridium perfringensenterotoxin. Acta Crystallographica Section F 66 (7), pp. 794-797. ISSN 1744-3091.
28 February 2020
Jones, M. and Beuron, F. and Borg, A. and Nans, A. and Earl, C.P. and Briggs, D.C. and Snijders, A.P. and Bowles, M. and Morris, E.P. and Linch, M. and McDonald, Neil Q. (2020) Cryo-EM structures of the XPF-ERCC1 endonuclease reveal how DNA-junction engagement disrupts an auto-inhibited conformation. Nature Communications 11 , p. 1120. ISSN 2041-1723.
14 May 2020
Moccia, M. and Frett, B. and Zhang, L. and Lakkaniga, R. and Briggs, D.C. and Chauhan, R. and Brescia, A. and Federico, G. and Santoro, M. and McDonald, Neil Q. and Li, H. and Carlomagno, F. (2020) Bioisosteric discovery of NPA101.3, a second generation RET/VEGFR2 inhibitor optimized for single-agent polypharmacology. Journal of Medicinal Chemistry 63 (9), pp. 4506-4516. ISSN 0022-2623.
1 July 2021
Adams, S.E. and Purkiss, A.G. and Knowles, P.P. and Nans, A. and Briggs, D.C. and Borg, A. and Earl, C.P. and Goodman, K.M. and Nawrotek, A. and Borg, A.J. and McIntosh, P.B. and Houghton, F.M. and Kjær, S. and McDonald, Neil Q. (2021) A two-site flexible clamp mechanism for RET-GDNF-GFRα1 assembly reveals both conformational adaptation and strict geometric spacing. Structure 29 (7), 694-708.e7. ISSN 0969-2126.
27 January 2022
Zhang, L. and Moccia, M. and Briggs, D.C. and Bharate, J.B. and Lakkaniga, N.R. and Knowles, P. and Tran, P. and Kharbanda, A. and Wang, X. and Leung, Y.-K. and Frett, B. and Santoro, M. and McDonald, Neil Q. and Carlomagno, F. and Li, H.-y. (2022) Discovery of N-trisubstituted Pyrimidine Derivatives as Type-I RET and RET Gatekeeper Mutant Inhibitors with a Novel Kinase Binding Pose. Journal of Medicinal Chemistry 65 (2), pp. 1536-1551. ISSN 0022-2623.
13 October 2023
Houghton, F.M. and Adams, S.E. and Rios, A.S. and Masino, L. and Purkiss, A.G. and Briggs, D.C. and Ledda, F. and McDonald, Neil Q. (2023) Architecture and regulation of a GDNF-GFRa1 synaptic adhesion assembly. Nature Communications , ISSN 2041-1723. (Submitted)