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    Article

    Meier, C. and Brookings, D.C. and Ceska, T.A. and Doyle, C. and Gong, H. and McMillan, D. and Saville, G.P. and Mushtaq, A. and Knight, D. and Reich, S. and Pearl, L.H. and Powell, K.A. and Savva, Renos and Allen, R.A. (2012) Engineering human MEK-1 for structural studies: a case study of combinatorial domain hunting. Journal of Structural Biology 177 (2), pp. 329-334. ISSN 1047-8477.

    Mollapour, M. and Tsutsumi, T. and Truman, A.W. and Xu, W. and Vaughan, Cara K. and Beebe, K. and Konstantinova, A. and Vourganti, S. and Panaretou, B. and Piper, P.W. and Trepel, J.B. and Prodromou, C. and Pearl, L.H. and Neckers, L. (2011) Threonine 22 Phosphorylation attenuates Hsp90 interaction with Cochaperones and affects its chaperone activity. Molecular Cell 41 (6), pp. 672-681. ISSN 1097-2765.

    Maclagan, K. and Tommasi, R. and Laurine, E. and Prodromou, C. and Driscoll, P.C. and Pearl, L.H. and Reich, S. and Savva, Renos (2011) A combinatorial method to enable detailed investigation of protein-protein interactions. Future Medicinal Chemistry 3 (3), pp. 271-282. ISSN 1756-8919.

    Vaughan, Cara K. and Piper, P.W. and Pearl, L.H. and Prodromou, C. (2009) A common conformationally coupled ATPase mechanism for yeast and human cytoplasmic HSP90s. FEBS Journal 276 (1), pp. 199-209. ISSN 1742-464X.

    Nilapwar, S. and Smith, E.P. and Fu, C. and Prodromou, C. and Pearl, L.H. and Williams, Mark A. and Ladbury, J.E. (2009) Structural-thermodynamics relationships of interactions in the N-terminal ATP binding domain of Hsp90. Journal of Molecular Biology 392 (4), pp. 923-936. ISSN 0022-2836.

    Nilapwar, S. and Williams, E. and Fu, C. and Prodromou, C. and Pearl, L.H. and Williams, Mark A. and Ladbury, J.E. (2009) Structural–thermodynamic relationships of interactions in the N-Terminal ATP-Binding domain of Hsp90. Journal of Molecular Biology 392 (4), pp. 923-936. ISSN 0022-2836.

    Vaughan, Cara K. and Mollapour, M. and Smith, J.R. and Truman, A.W. and Hu, B. and Good, V.M. and Panaretou, B. and Neckers, L. and Clarke, P.A. and Workman, P. and Piper, P.W. and Prodromou, C. and Pearl, L.H. (2008) Hsp90-dependent activation of protein kinases is regulated by chaperone-targeted dephosphorylation of Cdc37. Molecular Cell 31 (6), pp. 886-895. ISSN 1097-2765.

    Millson, S.H. and Vaughan, Cara K. and Zhai, C. and Ali, M.M.U. and Panaretou, B. and Piper, P.W. and Pearl, L.H. and Prodromou, C. (2008) Chaperone ligand-discrimination by the TPR-domain protein Tah1. Biochemical Journal 413 , pp. 261-268. ISSN 0264-6021.

    Hawkins, T.A. and Haramis, A.P. and Etard, C. and Prodromou, C. and Vaughan, Cara K. and Ashworth, R. and Ray, S. and Behra, M. and Holder, N. and Talbot, W.S. and Pearl, L.H. and Strahlem, U. and Wilson, S.W. (2008) The ATPase-dependent chaperoning activity of Hsp90a regulates thick filament formation and integration during skeletal muscle myofibrillogenesis. Development 135 , pp. 1147-1156. ISSN 0950-1991.

    Reich, S. and Puckey, L.H. and Cheetham, C.L. and Harris, R. and Ali, A.A. and Bhattacharyya, U. and Maclagan, K. and Powell, K.A. and Prodromou, C. and Pearl, L.H. and Driscoll, P.C. and Savva, Renos (2006) Combinatorial domain hunting: an effective approach for the identification of soluble protein domains adaptable to high-throughput applications. Protein Science 15 (10), pp. 2356-2365. ISSN 0961-8368.

    Barrett, T.E. and Schärer, O.D. and Savva, Renos and Brown, T. and Jiricny, J. and Verdine, G.L. and Pearl, L.H. (1999) Crystal structure of a thwarted mismatch glycosylase DNA repair complex. Embo Journal 18 (23), pp. 6599-6609. ISSN 0261-4189.

    Barrett, T.E. and Savva, Renos and Panayotou, G. and Barlow, T. and Brown, T. and Jiricny, J. and Pearl, L.H. (1998) Crystal structure of a G:T/U mismatch-specific DNA glycosylase: mismatch recognition by complementary-strand interactions. Cell 92 (1), pp. 117-129. ISSN 0092-8674.

    Panayotou, G. and Brown, T. and Barlow, T. and Pearl, L.H. and Savva, Renos (1998) Direct measurement of the substrate preference of uracil-DNA glycosylase. Journal of Biological Chemistry 273 (1), pp. 45-50. ISSN 0021-9258.

    Barrett, T.E. and Savva, Renos and Barlow, T. and Brown, T. and Jiricny, J. and Pearl, L.H. (1998) Structure of a DNA base-excision product resembling a cisplatin inter-strand adduct. Nature Structural Biology 5 (8), pp. 697-701. ISSN 1072-8368.

    Koulis, A. and Cowan, D.A. and Pearl, L.H. and Savva, Renos (1996) Uracil-DNA glycosylase activities in hyperthermophilic micro-organisms. FEMS Microbiology Letters 143 (2-3), pp. 267-271. ISSN 0378-1097.

    Pearl, L.H. and Savva, Renos (1996) The problem with Pyrimidines. Nature Structural Biology 3 (6), pp. 485-487. ISSN 1072-8368.

    Savva, Renos and Pearl, L.H. (1995) Cloning and expression of the uracil-DNA glycosylase inhibitor (UGI) from bacteriophage PBS-1 and crystallization of a uracil-DNA glycosylase-UGI complex. Proteins: Structure, Function, and Bioinformatics 22 (3), pp. 287-289. ISSN 0887-3585.

    Pearl, L.H. and Savva, Renos (1995) DNA repair in three dimensions. Trends in Biochemical Sciences 20 (10), pp. 421-426. ISSN 0968-0004.

    Savva, Renos and Pearl, L.H. (1995) Nucleotide mimicry in the crystal structure of the uracil-DNA glycosylase-uracil glycosylase inhibitor protein complex. Nature Structural Biology 2 (9), pp. 752-757. ISSN 1072-8368.

    Savva, Renos and Pearl, L.H. (1993) Crystallization and preliminary X-ray analysis of the uracil-DNA glycosylase DNA repair enzyme from herpes simplex virus type 1. Journal of Molecular Biology 234 (3), pp. 910-912. ISSN 0022-2836.

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