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ACS Catalysis

Roddan, Rebecca and Gygli, G. and Sula, Altin and Méndez-Sánchez, D. and Pleiss, J. and Ward, J.M. and Keep, Nicholas H. and Hailes, H.C. (2019) The acceptance and kinetic resolution of alpha-Methyl Substituted Aldehydes by Norcoclaurine Synthase. ACS Catalysis 9 (10), pp. 9640-9649. ISSN 2155-5435.

Acta Crystallographica Section F: Structural Biology Communications

Chauviac, Francois-Xavier and Robertson, Giles and Quay, Doris H.X. and Bagneris, Claire and Dumas, C. and Henderson, B. and Ward, J. and Keep, Nicholas H. and Cohen-Gonsaud, Martin (2014) RpfC (Rv1884) atomic structure shows high structural conservation within the resuscitation promoting factor catalytic domain. Acta Crystallographica Section F: Structural Biology Communications F70 (8), pp. 1022-1026. ISSN 1744-3091.

BMC Structural Biology

Quay, Doris H.X. and Cole, Ambrose R. and Cryar, A. and Thalassinos, Konstantinos and Williams, Mark A. and Bhakta, Sanjib and Keep, Nicholas H. (2015) Structure of the stationary phase survival protein YuiC from B.subtilis. BMC Structural Biology 15 (12), ISSN 1472-6807.

Sula, Altin and Cole, Ambrose R. and Yeats, C. and Orengo, C. and Keep, Nicholas H. (2014) Crystal structures of the human Dysferlin inner DysF domain. BMC Structural Biology 14 (3), ISSN 1472-6807.

Biochemical Journal

Garg, R. and Riento, K. and Keep, Nicholas H. and Morris, J.D.H. and Ridley, A.J. (2008) N-terminus-mediated dimerization of ROCK-1 is required for RhoE binding and actin reorganization. Biochemical Journal 411 , pp. 407-414. ISSN 0264-6021.

Biochemistry

Keep, Nicholas H. and Sula, Altin (2017) Structural evidence for the dopamine-first mechanism of norcoclaurine synthase. Biochemistry 56 (40), pp. 5274-5277. ISSN 0006-2960.

Current Opinion in Chemical Biology

Roddan, R. and Ward, J.M. and Keep, Nicholas H. and Hailes, H.C. (2020) Pictet-Spenglerases in Alkaloid Biosynthesis: future applications in Biocatalysis. Current Opinion in Chemical Biology 55 , pp. 69-76. ISSN 1367-5931.

FEBS Journal

Lichman, B.R. and Gershater, M.C. and Lamming, E.D. and Pesnot, T. and Sula, Altin and Keep, Nicholas H. and Hailes, H.C. and Ward, J.M. (2015) 'Dopamine-first' mechanism enables the rational engineering of the norcoclaurine synthase aldehyde activity profile. FEBS Journal 282 (6), pp. 1137-1151. ISSN 1742-464X.

Evangelopoulos, Dimitrios and Cronin, Nora and Daviter, Tina and Sim, E. and Keep, Nicholas H. and Bhakta, Sanjib (2011) Characterization of an oxidoreductase from the arylamine N-acetyltransferase operon in Mycobacterium Smegmatis. FEBS Journal 278 (24), pp. 4824-4832. ISSN 1742-464X.

FEMS Microbiology Reviews

Maitra, Arundhati and Munshi, Tulika and Healy, J. and Martin, L.T. and Vollmer, W. and Keep, Nicholas H. and Bhakta, Sanjib (2019) Cell wall peptidoglycan in Mycobacterium Tuberculosis: an Achilles’ heel for the TB-causing pathogen. FEMS Microbiology Reviews 43 (5), pp. 548-575. ISSN 1574-6976.

JAC-Antimicrobial Resistance

Maitra, Arundhati and Nukala, Syamasundari and Dickman, R. and Martin, Liam T. and Munshi, Tulika and Gupta, Antima and Shepherd, Adrian J. and Arnvig, K.B. and Tabor, A.B. and Keep, Nicholas H. and Bhakta, Sanjib (2021) Characterization of the MurT/GatD complex in Mycobacterium tuberculosis towards validating a novel anti-tubercular drug target. JAC-Antimicrobial Resistance 3 (1), ISSN 2632-1823.

Journal of Biological Chemistry

Chauviac, Francois-Xavier and Bommer, M. and Yan, Jun and Parkin, G. and Daviter, Tina and Lowden, Philip A.S. and Raven, E. L. and Thalassinos, Konstantinos and Keep, Nicholas H. (2012) Crystal structure of reduced MsAcg a putative nitroreductase from Mycobacterium smegmatis, and a close homologue of Mycobacterium tuberculosis Acg. Journal of Biological Chemistry 287 , pp. 44372-44383. ISSN 0021-9258.

Journal of Biomolecular NMR

Cohen Gonsaud, M. and Barthe, P. and Pommier, F. and Harris, R. and Driscoll, P.C. and Keep, Nicholas H. and Roumestand, C. (2004) Letter to the Editor: 1H, 15N, and 13C chemical shift assignments of the resuscitation promoting factor domain of Rv1009 from Mycobacterium tuberculosis. Journal of Biomolecular NMR 30 (3), pp. 373-374. ISSN 0925-2738.

Journal of Molecular Biology

Clark, Alice and Egberts, W.V. and Kondrat, F.D.L. and Hilton, G.R. and Ray, N.J. and Cole, Ambrose and Carver, J.A. and Benesch, J.L.P. and Keep, Nicholas H. and Boelens, W.C. and Slingsby, Christine (2018) Terminal regions confer plasticity to the tetrameric assembly of human HspB2 and HspB3. Journal of Molecular Biology 430 (18B), pp. 3297-3310. ISSN 0022-2836.

Clark, Alice R. and Naylor, Claire E. and Bagneris, Claire and Keep, Nicholas H. and Slingsby, Christine (2011) Crystal structure of R120G disease mutant of human αB-Crystallin Domain Dimer shows closure of a groove. Journal of Molecular Biology 408 (1), pp. 118-134. ISSN 0022-2836.

Bagneris, Claire and Bateman, Orval A. and Naylor, Claire E. and Cronin, Nora and Boelens, W.C. and Keep, Nicholas H. and Slingsby, Christine (2009) Crystal structures of α-Crystallin Domain Dimers of αB-Crystallin and Hsp20. Journal of Molecular Biology 392 (5), pp. 1242-1252. ISSN 0022-2836.

Zhou, J.J. and Robertson, Giles and He, X. and Dufour, S. and Hooper, A.M. and Pickett, J.A. and Keep, Nicholas H. and Field, L.M. (2009) Characterisation of Bombyx mori odorant-binding proteins reveals that a general odorant-binding protein discriminates between sex pheromone components. Journal of Molecular Biology 389 (3), pp. 529-545. ISSN 0022-2836.

Patel, P. and Harris, R. and Geddes, Stella M. and Strehle, E.M. and Watson, J.D. and Bashir, R. and Bushby, K. and Driscoll, P.C. and Keep, Nicholas H. (2008) Solution structure of the inner DysF domain of myoferlin and implications for limb girdle muscular dystrophy type 2b. Journal of Molecular Biology 379 (5), pp. 981-990. ISSN 0022-2836.

Malaysian Journal of Microbiology

Quay, D.H.X. and Qureshi, A. and Bhakta, Sanjib and Keep, Nicholas H. (2018) Mutation studies of the Gene Encoding YuiC, a Stationary Phase Survival Protein in Bacillus subtilis. Malaysian Journal of Microbiology 14 (2), ISSN 2231-7538.

Molecular and Cellular Proteomics

Ziveri, J. and Chhuon, C. and Jamet, A. and Rytter, H. and Prigent, G. and Tros, F. and Barel, M. and Coureuil, M. and Lays, C. and Henry, T. and Keep, Nicholas H. and Guerrera, I.C. and Charbit, A. (2019) Critical role of a sheath phosphorylation site on the assembly and function of an atypical type VI secretion system. Molecular and Cellular Proteomics 18 (12), pp. 2418-2432. ISSN 1535-9476.

Nature Communications

Roddan, Rebecca and Keep, Nicholas H. and Sula, Altin (2020) Single step syntheses of (1 S)-aryltetrahydroisoquinolines by norcoclaurine synthases. Nature Communications 3 (170), ISSN 2041-1723.

Nature Structural & Molecular Biology

Densham, R. and Garvin, A. and Keep, Nicholas H. and Watts, F. and Morris, J. and Et, al (2016) Human BRCA1-BARD1 Ubiquitin ligase activity counters chromatin barriers to DNA resection. Nature Structural & Molecular Biology 23 , pp. 647-655. ISSN 1545-9993.

Nature Structural and Molecular Biology

Cohen Gonsaud, M. and Barthe, P. and Bagneris, Claire and Henderson, B. and Ward, J.M. and Roumestand, C. and Keep, Nicholas H. (2005) The structure of a resuscitation-promoting factor domain from Mycobacterium tuberculosis shows homology to lysozymes. Nature Structural and Molecular Biology 12 (3), pp. 270-273. ISSN 1545-9993.

PLoS One

Munshi, Tulika and Gupta, Antima and Evangelopoulos, Dimitrios and Guzman, Juan D. and Gibbons, S. and Keep, Nicholas H. and Bhakta, Sanjib (2013) Characterisation of ATP-Dependent Mur Ligases Involved in the Biogenesis of Cell Wall Peptidoglycan in Mycobacterium tuberculosis. PLoS One 8 (3), e60143. ISSN 1932-6203.

Protein & Cell

Basavannacharya, Chandrakala and Moody, P.R. and Munshi, T. and Cronin, Nora and Keep, Nicholas H. and Bhakta, Sanjib (2010) Essential residues for the enzyme activity of ATP-dependent MurE ligase from Mycobacterium tuberculosis. Protein & Cell 1 (11), pp. 1011-1022. ISSN 1674-800X.

Scientific Reports

Northey, Thomas and Venthur, H. and De Biasio, F. and Chauviac, Francois-Xavier and Cole, Ambrose and Lisboa Ribeiro Junior, K.A. and Grossi, G. and Falabella, P. and Field, L.M. and Keep, Nicholas H. and Zhou, J.J. (2016) Crystal structures and binding dynamics of Odorant-Binding Protein 3 from two aphid species Megoura viciae and Nasonovia ribisnigri. Scientific Reports 6 , p. 24739. ISSN 2045-2322.

The Journal of Cell Biology

Zihni, C. and Munro, P.M.G. and Elbediwy, A. and Keep, Nicholas H. and Terry, S.J. and Harris, J. and Balda, M.S. and Matter, K. (2013) Dbl3 drives Cdc42 signaling at the apical margin to regulate junction position and apical differentiation. The Journal of Cell Biology 204 (1), pp. 111-127. ISSN 0021-9525.

The Journal of Neuroscience

Harvey, K. and Duguid, I.C. and Alldred, M.J. and Beatty, S.E. and Ward, H. and Keep, Nicholas H. and Lingenfelter, S.E. and Pearce, B.R. and Lundgren, J.D. and Owens, Max J. and Smart, T.G. and Luscher, B. and Rees, M.I. and Harvey, R.J. (2004) The GDP-GTP exchange factor collybistin: an essential determinant of neuronal gephyrin clustering. The Journal of Neuroscience 24 (25), pp. 5816-5826. ISSN 0270-6474.

Trends in Biochemical Sciences

Cohen Gonsaud, M. and Keep, Nicholas H. and Davies, A.P. and Ward, J.M. and Henderson, B. and Labesse, G. (2004) Resuscitation-promoting factors possess a lysozyme-like domain. Trends in Biochemical Sciences 29 (1), pp. 7-10. ISSN 0968-0004.

Tuberculosis

Basavannacharya, Chandrakala and Robertson, Giles and Munshi, T. and Keep, Nicholas H. and Bhakta, Sanjib (2010) ATP-dependent MurE ligase in Mycobacterium tuberculosis: biochemical and structural characterisation. Tuberculosis 90 (1), pp. 16-24. ISSN 1472-9792.