Browse by Research Centre

2016

Chandrashekhar Lele, A. and Amarnath Mishra, D. and Karmila Kamil, T. and Bhakta, Sanjib and Sohel Degani, M. (2016) Repositioning of DHFR Inhibitors. Current Topics In Medicinal Chemistry 16 (19), pp. 2125-2143. ISSN 1568-0266.

Cordeiro de Amorim, Renato and Makarenkov, V. and Mirkin, Boris (2016) A-Wardpβ: effective hierarchical clustering using the Minkowski metric and a fast k-means initialisation. Information Sciences 370-1 , pp. 343-354. ISSN 0020-0255.

Cossé, M.M. and Hayward, Richard D. and Subtil, A. (2016) One face of Chlamydia trachomatis: the infectious elementary body. In: UNSPECIFIED (ed.) Current Topics in Microbiology and Immunology. Current Topics in Microbiology and Immunology 412. Berlin, Germany: Springer, pp. 35-58. ISBN 9783319712307.

Densham, R. and Garvin, A. and Keep, Nicholas H. and Watts, F. and Morris, J. and Et, al (2016) Human BRCA1-BARD1 Ubiquitin ligase activity counters chromatin barriers to DNA resection. Nature Structural & Molecular Biology 23 , pp. 647-655. ISSN 1545-9993.

Zeev-Ben-Mordehai, T. and Vasishtan, D. and Hernández Durán, A. and Vollmer, B. and White, P. and Prasad Pandurangan, A. and Siebert, C.A. and Topf, Maya and Grünewald, K. (2016) Two distinct trimeric conformations of natively membrane-anchored full-length herpes simplex virus 1 glycoprotein B. Proceedings of the National Academy of Sciences of the United States of America 113 (15), pp. 4176-4181. ISSN 0027-8424.

de Amorim, R.C. and Mirkin, Boris (2016) A clustering-based approach to reduce feature redundancy. In: Skulimowski, A.M.J. and Kacprzyk, J. (eds.) Knowledge, Information and Creativity Support Systems: Recent Trends, Advances and Solutions. Advances in Intelligent Systems and Computing 5 364. Springer, pp. 465-475. ISBN 9783319190891.

January 2016

Cabreiro, Filipe (2016) Metformin joins forces with microbes. Cell Host & Microbe 19 (1), pp. 1-3. ISSN 1931-3128.

Dodsworth, Steven and Chase, M.W. and Leitch, A.R. (2016) Is post-polyploidization diploidization the key to the evolutionary success of angiosperms? Botanical Journal of the Linnean Society 180 (1), pp. 1-5. ISSN 0024-4074.

Dodsworth, Steven and Chase, M.W. and Särkinen, T. and Knapp, S. and Leitch, A.R. (2016) Using genomic repeats for phylogenomics: a case study in wild tomatoes (Solanum section Lycopersicon: Solanaceae). Biological Journal of the Linnean Society 117 (1), pp. 96-105. ISSN 0024-4066.

Haq, I. and Irving, J. and Saleh, A.D. and Dron, L. and Regan-Mochrie, G.L. and Motamedi-Shad, N. and Hurst, J.R. and Gooptu, Bibek and Lomas, D.A. (2016) Deficiency mutations of α1-antitrypsin differentially affect folding, function and polymerization. American Journal of Respiratory Cell and Molecular Biology 54 (1), pp. 71-80. ISSN 1044-1549.

Timmermans, M.J.T.N. and Barton, C. and Haran, J. and Ahrens, D. and Culverwell, C.L. and Ollikainen, A. and Dodsworth, Steven and Foster, P.G. and Bocak, L. and Vogler, A.P. (2016) Family-level sampling of mitochondrial genomes in Coleoptera: compositional heterogeneity and phylogenetics. Genome Biology and Evolution 8 (1), pp. 161-175. ISSN 1759-6653.

11 January 2016

Kalscheuer, V.M. and James, V.M. and Himelright, M.L. and Long, P. and Oegema, R. and Jensen, C. and Bienek, M. and Hu, H. and Haas, S.A. and Topf, Maya and Hoogeboom, A.J.M. and Harvey, K. and Walikonis, R. and Harvey, R.J. (2016) Novel Missense Mutation A789V in IQSEC2 underlies X-Linked intellectual disability in the MRX78 family. Frontiers in Molecular Neuroscience 8 , ISSN 1662-5099.

14 January 2016

Hospenthal, M.K. and Redzej, A. and Dodson, K. and Ukleja, M. and Frenz, B. and Rodrigues, C. and Hultgren, S.J. and DiMaio, F. and Egelman, E.H. and Waksman, Gabriel (2016) Structure of a Chaperone-Usher Pilus reveals the molecular basis of rod uncoiling. Cell 164 , pp. 269-278. ISSN 0092-8674.

21 January 2016

Watermeyer, Jean M. and Hale, Victoria L. and Hackett, F. and Clare, Daniel K. and Cutts, E.E. and Vakonakis, I. and Fleck, R.A. and Blackman, M.J. and Saibil, Helen R. (2016) A spiral scaffold underlies cytoadherent knobs in Plasmodium falciparum-infected erythrocytes. Blood 127 (3), pp. 343-351. ISSN 0006-4971.

29 January 2016

Newton, R. and Bowler, K.A. and Burns, E.M. and Chapman, P.J. and Fairweather, E.E. and Fritzl, S.J.R. and Goldberg, K.M. and Hamilton, N.M. and Holt, S.V. and Hopkins, G.V. and Jones, S.D. and Jordan, A.M. and Lyons, A.J. and Nikki March, H. and McDonald, Neil Q. and Maguire, L.A. and Mould, D.P. and Purkiss, A.G. and Small, H.F. and Stowell, A.I.J. and Thomson, G.J. and Waddell, I.D. and Waszkowycz, B. and Watson, A.J. and Ogilvie, D.J. (2016) The discovery of 2-substituted phenol quinazolines as potent RET kinase inhibitors with improved KDR selectivity. European Journal of Medicinal Chemistry 112 , pp. 20-32. ISSN 0223-5234.

8 February 2016

Amaning Danquah, C. and Maitra, Arundhati and Gibbons, S. and Nicklin, Jane and Bhakta, Sanjib (2016) HT-SPOTi: a rapid Drug Susceptibility Test (DST) to evaluate antibiotic resistance profiles and novel chemicals for anti-infective drug discovery. Current Protocols in Microbiology 40 , ISSN 1934-8533.

9 February 2016

Schuergers, N. and Lenn, T. and Kampmann, R. and Meissner, M.V. and Esteves, T. and Temerinac-Ott, M. and Korvink, J.G. and Lowe, Alan R. and Mullineaux, C.W. and Wilde, A. (2016) Cyanobacteria use micro-optics to sense light direction. eLife 5 , ISSN 2050-084X.

12 February 2016

Naylor, Claire and Bagneris, Claire and DeCaen, P.G. and Sula, A. and Scaglione, A. and Clapham, D.E. and Wallace, Bonnie A. (2016) Molecular basis of ion permeability in a voltage-gated sodium channel. Embo Journal 35 (8), pp. 820-830. ISSN 0261-4189.

15 February 2016

Carroni, Marta and Saibil, Helen R. (2016) Cryo electron microscopy to determine the structure of macromolecular complexes. Methods 95 , pp. 78-85. ISSN 1046-2023.

Ronzoni, R. and Berardelli, R. and Medicina, D. and Sitia, R. and Gooptu, Bibek and Fra, A.M. (2016) Aberrant disulphide bonding contributes to the ER retention of alpha1-antitrypsin deficiency variants. Human Molecular Genetics 25 (4), pp. 642-650. ISSN 0964-6906.

March 2016

Papaioannou, D. and Geibel, S. and Kunze, M.B.A. and Kay, C.W.M. and Waksman, Gabriel (2016) Structural and biophysical investigation of the interaction of a mutant Grb2 SH2 domain (W121G) with its cognate phosphopeptide. Protein Science 25 (3), pp. 627-637. ISSN 0961-8368.

3 March 2016

Denyer, Michael P. and Pinheiro, D.Y. and Garden, O.A. and Shepherd, Adrian J. (2016) Missed, not missing: Phylogenomic evidence for the existence of Avian FoxP3. PLoS One 11 (3), e0150988. ISSN 1932-6203.

24 March 2016

Bhakta, Sanjib (2016) Design and synthesis of 1-((1,5-bis(4-chlorophenyl)-2-methyl-1H-pyrrol-3-yl)methyl)-4-methylpiperazine (BM212) and N-Adamantan-2-yl-N'-((E)-3,7-dimethyl-octa-2,6-dienyl)-ethane-1,2-diamine (SQ109) pyrrole hybrid derivatives: discovery of potent anti-tubercular agents effective against multi-drug resistant mycobacteria. Journal of Medicinal Chemistry 59 (6), pp. 2780-2793. ISSN 0022-2623.

31 March 2016

Kearns, Sinead and Lurz, R. and Orlova, Elena and Okorokov, A.L. (2016) Two p53 tetramers bind one consensus DNA response element. Nucleic Acids Research 44 (13), pp. 6185-6199. ISSN 0305-1048.

April 2016

Cabrita, Lisa D. and Cassaignau, Anaïs M.E. and Launay, Hélène M.M. and Waudby, Christopher A. and Wlodarski, Tomasz and Camilloni, C. and Karyadi, Maria-Evangelia and Robertson, Amy L. and Wang, Xiaolin and Wentink, Anne S. and Goodsell, Luke S. and Woolhead, C.A. and Vendruscolo, M. and Dobson, C.M. and Christodoulou, John (2016) A structural ensemble of a ribosome–nascent chain complex during cotranslational protein folding. Nature Structural & Molecular Biology 23 (4), pp. 278-285. ISSN 1545-9993.

1 April 2016

Baratchian, M. and Davis, C.A. and Shimizu, A. and Escors, D. and Bagneris, Claire and Barrett, Tracey E. and Collins, M.K. (2016) Distinct activation mechanisms of NF-κB regulator inhibitor of NF-κB Kinase (IKK) by isoforms of the Cell Death Regulator Cellular FLICE-like Inhibitory Protein (cFLIP)*. Journal of Biological Chemistry 291 , pp. 7608-7620. ISSN 0021-9258.

22 April 2016

Miller, Wayne and Miles, Andrew J. and Wallace, Bonnie A. (2016) Structure of the C-terminal domain of the Prokaryotic Sodium Channel Orthologue NsvBa. European Biophysics Journal with Biophysics letters 45 (8), pp. 807-814. ISSN 0175-7571.

Northey, Thomas and Venthur, H. and De Biasio, F. and Chauviac, Francois-Xavier and Cole, Ambrose and Lisboa Ribeiro Junior, K.A. and Grossi, G. and Falabella, P. and Field, L.M. and Keep, Nicholas H. and Zhou, J.J. (2016) Crystal structures and binding dynamics of Odorant-Binding Protein 3 from two aphid species Megoura viciae and Nasonovia ribisnigri. Scientific Reports 6 , p. 24739. ISSN 2045-2322.

25 April 2016

Waudby, C.A. and Ramos, A. and Cabrita, Lisa and Christodoulou, John (2016) Two-dimensional NMR lineshape analysis. Scientific Reports 6 , p. 24826. ISSN 2045-2322.

1 May 2016

Joseph, Agnel Praveen and Malhotra, S. and Burnley, T. and Wood, C. and Clare, D.K. and Winn, M. and Topf, Maya (2016) Refinement of atomic models in high resolution EM reconstructions using Flex-EM and local assessment. Methods 100 , pp. 42-49. ISSN 1046-2023.

3 May 2016

Deckert, Annika and Waudby, Christopher and Wlodarski, Tomasz and Wentink, Anne and Wang, Xiaolin and Kirkpatrick, John and Paton, Jack and Camilloni, C. and Kukic, P. and Dobson, C.M. and Vendruscolo, M. and Cabrita, Lisa and Christodoulou, John (2016) Structural characterization of the interaction of α-synuclein nascent chains with the ribosomal surface and trigger factor. Proceedings of the National Academy of Sciences of the United States of America 113 (18), pp. 5012-5017. ISSN 0027-8424.

4 May 2016

Terry, C. and Wenborn, A. and Gros, N. and Sells, J. and Joiner, S. and Hosszu, L.L.P. and Tattum, M.H. and Panico, Silvia and Clare, Daniel and Collinge, J. and Saibil, Helen R. and Wadsworth, J.D.F. (2016) Ex vivomammalian prions are formed of paired double helical prion protein fibrils. Open Biology 6 (5), p. 160035. ISSN 2046-2441.

11 May 2016

Brucoli, F. and Guzman, Juan David and Basher, M.A. and Evangelopoulos, Dimitrios and Mcmahon, Eleanor and Munshi, Tulika and McHugh, T.D. and Fox, K.R. and Bhakta, Sanjib (2016) DNA sequence-selective C8-linked pyrrolobenzodiazepine–heterocyclic polyamide conjugates show anti-tubercular-specific activities. The Journal of Antibiotics 69 , pp. 843-849. ISSN 0021-8820.

13 May 2016

Lukoyanova, N. and Hoogenboom, B.W. and Saibil, Helen R. (2016) The membrane attack complex, perforin and cholesterol-dependent cytolysin superfamily of pore-forming proteins. Journal of Cell Science 129 (11), pp. 2125-2133. ISSN 0021-9533.

16 May 2016

Stubenrauch, C. and Belousoff, M.J. and Hay, I.D. and Shen, H.-H. and Lillington, James and Tuck, K.L. and Peters, K.M. and Phan, M.-D. and Lo, A.W. and Schembri, M.A. and Strugnell, R.A. and Waksman, Gabriel and Lithgow, T. (2016) Effective assembly of fimbriae in Escherichia coli depends on the translocation assembly module nanomachine. Nature Microbiology 1 (7), p. 16064. ISSN 2058-5276.

31 May 2016

de la Guardia, Y. and Gilliat, A.F. and Hellberg, J. and Rennert, P. and Cabreiro, Filipe and Gems, D. (2016) Run-on of germline apoptosis promotes gonad senescence in C. elegans. Oncotarget 7 (26), ISSN 1949-2553.

June 2016

Maitra, Arundhati and Bates, S. and Shaik, M. and Evangelopoulos, Dimitrios and Abubakar, I. and McHugh, T.D. and Lipman, M. and Bhakta, Sanjib (2016) Repurposing drugs for treatment of tuberculosis: a role for non-steroidal anti-inflammatory drugs. British Medical Bulletin 118 (1), pp. 138-148. ISSN 1471-8391.

10 June 2016

Jeremy, G. and Stevens, J. and Lowe, Alan R. (2016) Single-molecule imaging to characterise the transport mechanism of the Nuclear Pore Complex. In: Leake, M.C. (ed.) Chromosome Architecture: Methods and Protocols. Methods in Molecular Biology 1431. New York, U.S.: Springer New York, pp. 17-35. ISBN 9781493936298.

17 June 2016

Vemu, A. and Atherton, Joe and Spector, J.O. and Szyk, A. and Moores, Carolyn A. and Roll-Mecak, A. (2016) Structure and dynamics of single-isoform recombinant Neuronal Human Tubulin. Journal of Biological Chemistry 291 (25), pp. 12907-12915. ISSN 0021-9258.

27 June 2016

Miles, Andrew J. and Wallace, Bonnie A. (2016) Circular dichroism spectroscopy of membrane proteins. Chemical Society Reviews 18 , pp. 4859-4872. ISSN 0306-0012.

28 June 2016

D'Auria, S. and Lopes, J.L.S. and Yoneda, Juliana and Martins, J.M. and DeMarco, R. and Jameson, D.M. and Castro, A.M. and Bossolan, N.R.S. and Wallace, Bonnie A. and Araujo, A.P.U. (2016) Environmental factors modulating the stability and enzymatic activity of the Petrotoga mobilis Esterase (PmEst). PLoS One 11 (6), e0158146. ISSN 1932-6203.

July 2016

Pilorge, M. and Fassier, C. and Le Corronc, H. and Potey, A. and Bai, J. and De Gois, S. and Delaby, E. and Assouline, B. and Guinchat, V. and Devillard, F. and Delorme, R. and Nygren, G. and Råstam, M. and Meier, J.C. and Otani, S. and Cheval, H. and James, V.M. and Topf, Maya and Dear, T.N. and Gillberg, C. and Leboyer, M. and Giros, B. and Gautron, S. and Hazan, J. and Harvey, R.J. and Legendre, P. and Betancur, C. (2016) Genetic and functional analyses demonstrate a role for abnormal glycinergic signaling in autism. Molecular Psychiatry 21 , pp. 936-945. ISSN 1359-4184.

Santos, A.J.M. and Durkin, C.H. and Helaine, S. and Boucrot, Emmanuel and Holden, D.W. and McCormick, B.A. (2016) Clustered Intracellular Salmonella enterica Serovar Typhimurium blocks host cell cytokinesis. Infection and Immunity 84 (7), pp. 2149-2158. ISSN 0019-9567.

1 July 2016

Bullock, Joshua and Schwab, J. and Thalassinos, Konstantinos and Topf, Maya (2016) The importance of non-accessible crosslinks and solvent accessible surface distance in modelling proteins with restraints from crosslinking mass spectrometry. Molecular & Cellular Proteomics 15 (7), pp. 2491-2500. ISSN 1535-9476.

Lopez-Fontal, Elkin and Milanesi, Lilia and Tomas, Salvador (2016) Multivalence cooperativity leading to “all-or-nothing” assembly: the case of nucleation-growth in supramolecular polymers. Chemical Science 7 (7), pp. 4468-4475. ISSN 2041-6520.

6 July 2016

Ashford, Paul and Hernandez duran, Anna and Greco, T.M. and Buch, A. and Sodeik, B. and Cristea, I.M. and Grünewald, K. and Shepherd, Adrian J. and Topf, Maya (2016) HVint: a strategy for identifying novel protein-protein interactions in Herpes Simplex Virus Type 1. Molecular & Cellular Proteomics 15 (9), pp. 2939-2953. ISSN 1535-9476.

28 July 2016

Cassaignau, A.M. and Launay, H.M. and Karyadi, M.E. and Wang, X. and Waudby, C.A. and Deckert, A. and Robertson, A.L. and Cabrita, Lisa and Christodoulou, John (2016) A strategy for co-translational folding studies of ribosome-bound nascent chain complexes using NMR spectroscopy. Nature Protocols 11 , pp. 1492-1507. ISSN 1754-2189.

29 July 2016

Gabreski, N.A. and Vaghasia, J.K. and Novakova, S.S. and McDonald, Neil Q. and Pierchala, B.A. (2016) Exon skipping in the RET Gene encodes novel isoforms that differentially regulate RET Protein signal transduction. Journal of Biological Chemistry 291 (31), pp. 16249-16262. ISSN 0021-9258.

August 2016

Dumoux, Maud and Hayward, Richard D. (2016) Membrane contact sites between pathogen-containing compartments and host organelles. Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids 1861 (8(B)), pp. 895-899. ISSN 1388-1981.

Hodel, A.W. and Leung Shin Cheung, Carl and Dudkina, Natalia and Saibil, Helen R. and Hoogenboom, B.W. (2016) Atomic force microscopy of membrane pore formation by cholesterol dependent cytolysins. Current Opinion in Structural Biology 39 (1), pp. 8-15. ISSN 0959-440X.

Tizei, P.A.G. and Csibra, E. and Torres, L. and Pinheiro, Vitor B. (2016) Selection platforms for directed evolution in synthetic biology. Biochemical Society Transactions 44 (4), pp. 1165-1175. ISSN 0300-5127.

9 August 2016

Oberoi, J. and Dunn, D. and Woodford, M. and Mariotti, L. and Schulman, J. and Bourboulia, D. and Mollapour, M. and Vaughan, Cara K. (2016) Structural and functional basis of protein phosphatase 5 substrate specificity. Proceedings of the National Academy of Sciences of the United States of America 113 (32), pp. 9009-9014. ISSN 0027-8424.

22 August 2016

McDonald, Neil Q. (2016) aPKC inhibition by Par3 CR3 flanking regions controls substrate access and underpins apical-junctional polarization. Developmental Cell 38 (4), pp. 384-398. ISSN 1534-5807.

23 August 2016

Hemming, Joanna M. and Hughes, Brian R. and Rennie, A. and Tomas, Salvador and Campbell, R. and Hughes, A. and Arnold, T. and Botchway, S. and Thompson, Katherine C. (2016) Environmental pollutant ozone causes damage to lung surfactant protein B, SP-B. Biochemistry 54 (33), pp. 5185-5197. ISSN 0006-2960.

8 September 2016

Costa, Tiago and Ilangovan, Aravindan and Ukleja, Marta and Redzej, Adam and Santini, Joanne and Smith, T.K. and Egelman, E.H. and Waksman, Gabriel (2016) Structure of the Bacterial Sex F Pilus reveals an assembly of a Stoichiometric Protein-Phospholipid Complex. Cell 166 (6), 1436-1444.e10. ISSN 0092-8674.

Whitmore, Lee and Miles, Andrew J. and Mavridis, L. and Janes, R.W. and Wallace, Bonnie A. (2016) PCDDB: new developments at the Protein Circular Dichroism Data Bank. Nucleic Acids Research 45 (D1), D303-D307. ISSN 0305-1048.

15 September 2016

Orcia, D. and Zeraik, A.E. and Lopes, J.L.S. and Macedo, J.N.A. and Santos, C.R.d. and Oliveira, K.C. and Anderson, L. and Wallace, Bonnie A. and Verjovski-Almeida, S. and Araujo, A.P.U. and DeMarco, R. (2016) Interaction of an esophageal MEG protein from schistosomes with a human S100 protein involved in inflammatory response. Biochimica et Biophysica Acta (BBA) - General Subjects 1861 (1A), pp. 3490-3497. ISSN 0304-4165.

October 2016

Ukleja, Marta and Valpuesta, J.M. and Dziembowski, A. and Cuellar, J. (2016) Beyond the known functions of the CCR4-NOT complex in gene expression regulatory mechanisms. BioEssays 38 (10), pp. 1048-1058. ISSN 0265-9247.

24 October 2016

Osborne, Andrew and Thalassinos, Konstantinos and Davies, Heledd (2016) Expansion of Lysine-rich repeats in Plasmodium proteins generates novel localisation sequences that target the periphery of the host Erythrocyte. Journal of Biological Chemistry 291 , pp. 26188-26207. ISSN 0021-9258.

9 November 2016

Britto, M. and Goulet, A. and Rizvi, S. and von Loeffelholz, O. and Moores, Carolyn A. and Cross, R.A. (2016) Schizosaccharomyces pombe kinesin-5 switches direction using a steric blocking mechanism. Proceedings of the National Academy of Sciences of the United States of America 113 (47), E7483-E7489. ISSN 0027-8424.

30 November 2016

Kerai, L.V. and Hilton, S. and Maugueret Minerve, Tafie and Kazi, Bilkis Banu and Nicklin, Jane and Bhakta, Sanjib and Murdan, S. (2016) UV-curable gels as topical nail medicines: in vivo residence, anti-fungal efficacy and influence of gel components on their properties. International Journal of Pharmaceutics 514 (1), pp. 244-254. ISSN 0378-5173.

Torres, L. and Kruger, A. and Csibra, E. and Gianni, E. and Pinheiro, Vitor B. (2016) Synthetic biology approaches to biological containment: pre-emptively tackling potential risks. Essays in Biochemistry 60 (4), pp. 393-410. ISSN 1744-1358.

December 2016

Dodsworth, Steven (2016) 848. Platystele misera: Orchidaceae. Curtis's Botanical Magazine 33 (4), pp. 294-302. ISSN 1355-4905.

Dodsworth, Steven and Guignard, M.S. and Hidalgo, O. and Leitch, I.J. and Pellicer, J. (2016) Digests: Salamanders’ slow slither into genomic gigantism. Evolution 70 (12), pp. 2915-2916.

1 December 2016

Dodsworth, Steven (2016) 849. Platystele ovatilabia: Orchidaceae. Curtis's Botanical Magazine 33 (4), pp. 303-309. ISSN 1355-4905.

20 December 2016

McDonald, Neil Q. (2016) RET functions as a dual-specificity kinase that requires allosteric inputs from juxtamembrane elements. Cell Reports 17 (12), pp. 3319-3332. ISSN 2211-1247.