Browse by Research Centre

2013

Bahi-Buisson, N. and Souville, I. and Fourniol, Franck J. and Toussaint, A. and Moores, Carolyn A. and Houdusse, A. and Yves Lemaitre, J. and Poirier, K. and Khalaf-Nazzal, R. and Hully, M. and Louis Leger, P. and Elie, C. and Boddaert, N. and Beldjord, C. and Chelly, J. and Francis, F. (2013) New insights into genotype-phenotype correlations for the doublecortin-related lissencephaly spectrum. Brain 136 (1), pp. 223-244. ISSN 1460-2156.

Chan, J.J. and Flatters, D. and Rodrigues-Lima, F. and Yan, J. and Thalassinos, Konstantinos and Katan, M. (2013) Comparative analysis of interactions of RASSF1-10. Advances in Biological Regulation 53 (2), pp. 190-201. ISSN 2212-4926.

Fadden, A.J. and Schalbetter, S. and Bowles, M. and Harris, R. and Lally, J. and Carr, A.M. and McDonald, Neil Q. (2013) A winged helix domain in human MUS81 binds DNA and modulates the endonuclease activity of MUS81 complexes. Nucleic Acids Research , ISSN 0305-1048.

Fourniol, Franck J. and Perderiset, M. and Houdusse, A. and Moores, Carolyn A. (2013) Structural studies of the Doublecortin family of MAPs. In: Correia, J.J. and Wilson, L. (eds.) Microtubules, In Vitro (2nd Edition). Methods In Cell Biology 115. New York, U.S.: Elsevier, pp. 27-48. ISBN 9780124077577.

Goulet, Adeline and Moores, Carolyn A. (2013) New insights into the mechanism of force generation by Kinesin-5 molecular motors. In: Jeon, K.W. (ed.) International Review of Cell and Molecular Biology. New York, U.S.: Elsevier, pp. 419-466. ISBN 9780124076969.

Lithgow, T. and Waksman, Gabriel (2013) Seaside transportation: from structure to function of translocation machines. EMBO reports 14 (7), pp. 585-587. ISSN 1469-221X.

Lowe, P.N. and Vaughan, Cara K. and Daviter, Tina (2013) Measurement of protein–ligand complex formation. In: Williams, Mark A. and Daviter, Tina (eds.) Protein–Ligand Interactions: Fundamentals. Methods in Molecular Biology I 1008. Berlin, Germany: Springer, pp. 63-99. ISBN 9781627033978.

Maitra, A. and Bhakta, Sanjib (2013) Mycobacterium tuberculosis... can we beat it? Report from Euroscicon 2013. Virulence , pp. 14-18. ISSN 2150-5594.

Munshi, Tulika and Gupta, Antima and Evangelopoulos, Dimitrios and Guzman, Juan D. and Gibbons, S. and Keep, Nicholas H. and Bhakta, Sanjib (2013) Characterisation of ATP-Dependent Mur Ligases Involved in the Biogenesis of Cell Wall Peptidoglycan in Mycobacterium tuberculosis. PLoS One 8 (3), e60143. ISSN 1932-6203.

Muretta, J.M. and Behnke-Parks, W.M. and Major, J. and Petersen, K.J. and Goulet, A. and Moores, Carolyn A. and Thomas, D.D. and Rosenfeld, S.S. (2013) Loop L5 assumes three distinct orientations during the ATpase cycle of the mitotic kinesin eg5: a transient and time-resolved flourescence study. Journal of Biological Chemistry 288 (48), pp. 34839-34849. ISSN 0021-9258.

Nascimento, S. and Felizardo, R. and Mirkin, Boris (2013) Laplacian normalization for deriving thematic fuzzy clusters with an additive spectral approach. Expert Systems , ISSN 0266-4720.

Rothwell, P.J. and Allen, W.J. and Sisamakis, E. and Kalinin, S. and Felekyan, S. and Widengren, J. and Waksman, Gabriel and Seidel, C.A.M. (2013) dNTP-dependent conformational transitions in the fingers subdomain of klentaq1 DNA polymerase: insights into the role of the "nucleotide-binding" state. Journal of Biological Chemistry 288 (19), pp. 13575-13591. ISSN 0021-9258.

Temussi, P.A. and Waudby, Christopher A. and Camilloni, C. and Fitzpatrick, A.W.P. and Cabrita, L.D. and Dobson, C.M. and Vendruscolo, M. and Christodoulou, John (2013) In-cell NMR characterization of the secondary structure populations of a disordered conformation of α-Synuclein within E. coli cells. PLoS One 8 (8), e72286. ISSN 1932-6203.

Volkan, E. and Kalas, V. and Pinkner, J.S. and Dodson, K.W. and Henderson, N.S. and Pham, T. and Waksman, Gabriel and Delcour, A.H. and Thanassi, D.G. and Hultgren, S.J. (2013) Molecular basis of usher pore gating in Escherichia coli pilus biogenesis. Proceedings of the National Academy of Sciences of the United States of America 110 (51), pp. 20741-20746. ISSN 0027-8424.

Williams, Mark A. (2013) Protein-ligand interactions: fundamentals. In: Williams, Mark A. and Daviter, Tina (eds.) Protein–Ligand Interactions: Fundamentals. Methods in Molecular Biology I 1008. Berlin, Germany: Springer, pp. 3-34. ISBN 9781627033978.

Wynne, S.A. and Pinheiro, Vitor B. and Holliger, P. and Leslie, A.G.W. (2013) Structures of an apo and a binary complex of an evolved archeal b family DNA polymerase capable of synthesising highly cy-dye labelled DNA. PLoS One 8 (8), ISSN 1932-6203.

d'Avanzo, N. and McCusker, Emily C. and Powl, Andrew M. and Miles, Andrew J. and Nichols, C.G. and Wallace, Bonnie A. (2013) Differential lipid dependence of function of bacterial sodium channel homologues. Biophysical Journal 104 (2), 14a. ISSN 0006-3495.

29 January 2013

Ulmschneider, Martin B. and Bagneris, Claire and McCusker, Emily C. and Ulmschneider, J.P. and Wallace, Bonnie A. (2013) Microsecond molecular dynamics simulations of the open state structure of a bacterial voltage-gated sodium channel reveal mechanisms of ion selectivity and conduction. Biophysical Journal 104 (2), 132a-133a. ISSN 0006-3495.

February 2013

Riaz, A. and Nicklin, Jane and Haque, I. and Abdur Rauf, C. and Qadir, G. and Naz, F. (2013) Toxicity induced by Solanapyrone A in Chickpea shoots and its metabolism through Glutathione/Glutathione-S-Transferase system. Pakistan Journal of Botany 45 (1), pp. 135-139. ISSN 0556-3321.

Tarr, Sarah J. and Cryar, Adam and Thalassinos, Konstantinos and Haldar, K. and Osborne, Andrew R. (2013) The C-terminal portion of the cleaved HT motif is necessary and sufficient to mediate export of proteins from the malaria parasite into its host cell. Molecular Microbiology 87 (4), pp. 835-850. ISSN 0950-382X.

1 February 2013

Savva, Christos G. and Fernandes da Costa, S.P. and Bokori-Brown, M. and Naylor, Claire E. and Cole, Ambrose R. and Moss, David S. and Titball, R.W. and Basak, Ajit K. (2013) Molecular architecture and functional analysis of NetB, a pore-forming toxin from Clostridium perfringens. Journal of Biological Chemistry 288 , pp. 3512-3522. ISSN 0021-9258.

5 February 2013

Slingsby, Christine and Clark, Alice R. (2013) Flexible nanoassembly for sequestering non-native proteins. Structure 21 (2), pp. 193-194. ISSN 0969-2126.

March 2013

Allen, William J. and Phan, Gilles and Hultgren, S.J. and Waksman, Gabriel (2013) Dissection of pilus tip assembly by the FimD usher monomer. Journal of Molecular Biology 425 (5), pp. 958-967. ISSN 0022-2836.

Pandurangan, A.P. and Shakeel, S. and Butcher, S. and Topf, Maya (2013) Combined approaches to flexible fitting and assessment in virus capsids undergoing conformational change. Journal of Structural Biology 185 (3), pp. 427-439. ISSN 1047-8477.

1 March 2013

Saibil, Helen R. (2013) Machinery to reverse irreversible aggregates. Science 339 (6123), pp. 1040-1041. ISSN 0036-8075.

22 March 2013

Yuan, Shujun and Topf, Maya and Reubold, T.F. and Eschenburg, S. and Akey, C.W. (2013) Changes in Apaf-1 conformation that drive apoptosome assembly. Biochemistry 52 (13), pp. 2319-2327. ISSN 0006-2960.

April 2013

Geibel, Sebastien and Procko, E. and Hultgren, S.J. and Baker, D. and Waksman, Gabriel (2013) Structural and energetic basis of folded-protein transport by the FimD usher. Nature 496 (7444), pp. 243-246. ISSN 0028-0836.

James, Victoria M. and Bode, A. and Chung, S.-K. and Gill, J.L. and Nielsen, M. and Cowan, Frances M. and Vujic, M. and Thomas, R.H. and Rees, M.I. and Harvey, K. and Keramidas, A. and Topf, Maya and Ginjaar, I. and Lynch, J.W. and Harvey, R.J. (2013) Novel missense mutations in the glycine receptor β subunit gene (GLRB) in startle disease. Neurobiology of Disease 52 , pp. 137-149. ISSN 0969-9961.

Lo, A.W. and Van de Water, K. and Gane, P.J. and Chan, A.W. and Steadman, David and Stevens, Kiri and Selwood, D.L. and Waksman, Gabriel and Remaut, H. (2013) Suppression of type 1 pilus assembly in uropathogenic Escherichia coli by chemical inhibition of subunit polymerization. Journal of Antimicrobial Chemotherapy 69 (4), pp. 1017-1026. ISSN 1460-2091.

Mirkin, Boris and Gutman, P.O. (2013) Tube model reference adaptive control. Automatica 49 (4), pp. 1012-1018. ISSN 0005-1098.

Slingsby, Christine and Wistow, G.J. and Clark, Alice R. (2013) Evolution of crystallins for a role in the vertebrate eye lens. Protein Science 22 (4), pp. 367-380. ISSN 0961-8368.

4 April 2013

Lopez, J.A. and Susanto, O. and Jenkins, M.R. and Lukoyanova, Natalya and Sutton, V.R. and Law, R.H.P. and Johnston, A. and Bird, C.H. and Bird, P I. and Whisstock, J.C. and Trapani, J.A. and Saibil, Helen R. and Voskoboinik, I. (2013) Perforin forms transient pores on the target cell plasma membrane to facilitate rapid access of granzymes during killer cell attack. Blood 121 (14), pp. 2659-2668. ISSN 0006-4971.

8 April 2013

van Veen, H.W. and d'Avanzo, N. and McCusker, Emily C. and Powl, Andrew M. and Miles, Andrew J. and Nichols, C.G. and Wallace, Bonnie A. (2013) Differential lipid dependence of the function of bacterial sodium channels. PLoS One 8 (4), e61216. ISSN 1932-6203.

9 April 2013

Thompson, Katherine C. and Jones, S.H. and Rennie, A.R. and King, M.D. and Ward, A.D. and Hughes, Brian R. and Lucas, C.O.M. and Campbell, R.A. and Hughes, A.V. (2013) Degradation and rearrangement of a lung surfactant lipid at the air–water interface during exposure to the pollutant gas ozone. Langmuir 29 (14), pp. 4594-4602. ISSN 0743-7463.

16 April 2013

Ulmschneider, Martin B. and Bagneris, Claire and McCusker, Emily C. and DeCaen, P.G. and Delling, M. and Clapham, D.E. and Ulmschneider, J.P. and Wallace, Bonnie A. (2013) Molecular dynamics of ion transport through the open conformation of a bacterial voltage-gated sodium channel. Proceedings of the National Academy of Sciences of the United States of America 110 (16), pp. 6364-6369. ISSN 0027-8424.

17 April 2013

Rivera-Calzada, A. and Fronzes, Remi and Savva, Christos G. and Chandran, Vidya and Lian, Pei W. and Laeremans, T. and Pardon, E. and Steyaert, J. and Remaut, Han and Waksman, Gabriel and Orlova, Elena (2013) Structure of a bacterial type IV secretion core complex at subnanometre resolution. The EMBO Journal 32 (8), pp. 1195-1204. ISSN 1460-4189.

25 April 2013

Riou, P. and Kjær, S. and Garg, R. and Purkiss, Andrew G. and George, R. and Cain, R.J. and Bineva, G. and Reymond, N. and McColl, B. and Thompson, A.J. and O’Reilly, N. and McDonald, Neil Q. and Parker, P.J. and Ridley, A.J. (2013) 14-3-3 Proteins Interact with a Hybrid Prenyl-Phosphorylation Motif to Inhibit G Proteins. Cell 153 (3), pp. 640-653. ISSN 0092-8674.

May 2013

Bokori-Brown, M. and Kokkinidou, M.C. and Savva, Christos G. and Fernandes da Costa, S.P. and Naylor, Claire E. and Cole, Ambrose R. and Moss, David S. and Basak, Ajit K. and Titball, R.W. (2013) Clostridium perfringensepsilon toxin H149A mutant as a platform for receptor binding studies. Protein Science 22 (5), pp. 650-659. ISSN 0961-8368.

Bokori-Brown, M. and Kokkinidou, M.C. and Savva, Christos G. and Fernandes da Costa, S.P. and Naylor, Claire E. and Cole, Ambrose R. and Moss, David S. and Basak, Ajit K. and Titball, R.W. (2013) Clostridium perfringensepsilon toxin H149A mutant as a platform for receptor binding studies. Protein Science 22 (5), pp. 650-659. ISSN 0961-8368.

Khan, N.A. and Ajmal, M. and Nicklin, Jane and Aslam, S. and Asif Ali, M. (2013) Nutritional value of Pleurotus (Flabellatus) Djamor (R-22) cultivated on sawdusts of different woods. Pakistan Journal of Botany 45 (3), pp. 1105-1108. ISSN 0556-3321.

13 May 2013

Saibil, Helen R. and Fenton, W. and Clare, Daniel K. and Horwich, A.L. (2013) Structure and allostery of the Chaperonin GroEL. Journal of Molecular Biology 425 (9), pp. 1476-1487. ISSN 0022-2836.

31 May 2013

Miles, Andrew J. and Fedosova, N.U. and Hoffmann, S.V. and Wallace, Bonnie A. and Esmann, M. (2013) Stabilisation of Na,K-ATPase structure by the cardiotonic steroid ouabain. Biochemical and Biophysical Research Communications 435 (2), pp. 300-305. ISSN 0006-291X.

June 2013

Guzman, Juan D. and Evangelopoulos, Dimitrios and Gupta, Antima and Birchall, K. and Mwaigwisya, S. and Saxty, B. and McHugh, T.D. and Gibbons, S. and Malkinson, J. and Bhakta, Sanjib (2013) Antitubercular specific activity of ibuprofen and the other 2-arylpropanoic acids using the HT-SPOTi whole-cell phenotypic assay. BMJ Open 3 (6), e002672. ISSN 2044-6055.

1 June 2013

Haq, I. and Irving, J.A. and Faull, S.V. and Dickens, J.A. and Ordóñez, A. and Belorgey, D. and Gooptu, Bibek and Lomas, D.A. (2013) Reactive centre loop mutants of α-1-antitrypsin reveal position-specific effects on intermediate formation along the polymerization pathway. Bioscience Reports 33 (3), pp. 499-511. ISSN 0144-8463.

4 June 2013

Lopes, J.L.S. and Orcia, D. and Araujo, A.P.U. and DeMarco, R. and Wallace, Bonnie A. (2013) Folding factors and partners for the intrinsically disordered protein Micro-Exon Gene 14 (MEG-14). Biophysical Journal 104 (11), pp. 2512-2520. ISSN 0006-3495.

26 June 2013

Lillington, James and Waksman, Gabriel (2013) Ordered and ushered; the assembly and translocation of the adhesive Type I and P Pili. Biology 2 (3), pp. 841-860. ISSN 2079-7737.

28 June 2013

Housden, N.G. and Hopper, J.T.S. and Lukoyanova, Natalya and Rodriguez-Larrea, D. and Wojdyla, J.A. and Klein, A. and Kaminska, R. and Bayley, H. and Saibil, Helen R. and Robinson, C.V. and Kleanthous, C. (2013) Intrinsically disordered protein threads through the bacterial outer-membrane Porin OmpF. Science 340 (6140), pp. 1570-1574. ISSN 0036-8075.

July 2013

Guzman, Juan D. and Evangelopoulos, Dimitrios and Gupta, Antima and Prieto, J.M. and Gibbons, S. and Bhakta, Sanjib (2013) Antimycobacterials from Lovage Root (Ligusticum officinale Koch). Phytotherapy Research 27 (7), pp. 993-998. ISSN 0951-418X.

Redzej, Adam and Ilangovan, Aravindan and Lang, S. and Gruber, C.J. and Topf, Maya and Zangger, K. and Zechner, E.L. and Waksman, Gabriel (2013) Structure of a translocation signal domain mediating conjugative transfer by Type IV secretion systems. Molecular Microbiology 89 (2), pp. 324-333. ISSN 0950-382X.

Woollett, Benjamin and Whitmore, Lee and Janes, R.W. and Wallace, Bonnie A. (2013) ValiDichro: a website for validating and quality control of protein circular dichroism spectra. Nucleic Acids Research 41 (W1), W417-W421. ISSN 0305-1048.

1 July 2013

Sivalingam, G.N. and Yan, Jun and Sahota, Harpal and Thalassinos, Konstantinos (2013) Amphitrite: a program for processing travelling wave ion mobility mass spectrometry data. International Journal of Mass Spectrometry 345 , pp. 54-62. ISSN 1387-3806.

10 July 2013

Grochmal, Anna and Ferrero, E. and Milanesi, Lilia and Tomas, Salvador (2013) Modulation of in-membrane receptor clustering upon binding of multivalent ligands. Journal of the American Chemical Society 135 (27), pp. 10172-10177. ISSN 0002-7863.

August 2013

Fernandez, D.I. and Sani, M.-A. and Miles, Andrew J. and Wallace, Bonnie A. and Separovic, F. (2013) Membrane defects enhance the interaction of antimicrobial peptides, aurein 1.2 versus caerin 1.1. Biochimica et Biophysica Acta (BBA) - Biomembranes 1828 (8), pp. 1863-1872. ISSN 0006-3002.

6 August 2013

Maurer, U.E. and Zeev-Ben-Mordehai, T. and Pandurangan, Arun and Cairns, T.M. and Hannah, B.P. and Whitbeck, J.C. and Eisenberg, R.J. and Cohen, G.H. and Topf, Maya and Huiskonen, J.T. and Grünewald, K. (2013) The structure of Herpesvirus Fusion Glycoprotein B-Bilayer Complex reveals the protein-membrane and lateral protein-protein interaction. Structure 21 (8), pp. 1396-1405. ISSN 0969-2126.

3 September 2013

Coulthard, R. and Deans, A.J. and Swuec, P. and Bowles, M. and Costa, A. and West, S.C. and McDonald, Neil Q. (2013) Architecture and DNA recognition elements of the Fanconi Anemia FANCM-FAAP24 Complex. Structure 21 (9), pp. 1648-1658. ISSN 0969-2126.

Thalassinos, Konstantinos and Pandurangan, Arun and Xu, M. and Alber, F. and Topf, Maya (2013) Conformational states of macromolecular assemblies explored by integrative structure calculation. Structure 21 (9), pp. 1500-1508. ISSN 0969-2126.

19 September 2013

Bagneris, Claire and DeCaen, P.G. and Hall, B.A. and Naylor, Claire E. and Clapham, D.E. and Kay, C.W.M. and Wallace, Bonnie A. (2013) Role of the C-terminal domain in the structure and function of tetrameric sodium channels. Nature Communications 4 , p. 2465. ISSN 2041-1723.

26 September 2013

Costi, R. and Crucitti, G.C. and Pescatori, L. and Messore, A. and Scipione, L. and Tortorella, S. and Amoroso, A. and Crespan, E. and Campiglia, P. and Maresca, B. and Porta, A. and Granata, I. and Novellino, E. and Gouge, Jerome and Delarue, M. and Maga, G. and Di Santo, R. (2013) New nucleotide-competitive non-nucleoside inhibitors of terminal deoxynucleotidyl transferase: discovery, characterization, and crystal structure in complex with the target. Journal of Medicinal Chemistry 56 (18), pp. 7431-41. ISSN 0022-2623.

October 2013

Atherton, Joseph and Houdusse, A. and Moores, Carolyn A. (2013) MAPping out distribution routes for kinesin couriers. Biology of the Cell 105 (10), pp. 465-487. ISSN 0248-4900.

Cole, Ambrose R. and Ofer, Sapir and Ryzhenkova, Ksenia and Baltulionis, Gediminas and Hornyak, Peter and Savva, Renos (2013) Architecturally diverse proteins converge on an analogous mechanism to inactivate Uracil-DNA glycosylase. Nucleic Acids Research 41 (18), pp. 8760-8775. ISSN 0305-1048.

Saibil, Helen R. (2013) Chaperone machines for protein folding, unfolding and disaggregation. Nature Reviews Molecular Cell Biology 14 (10), pp. 630-642. ISSN 1471-0072.

Waudby, Christopher A. and Launay, H. and Cabrita, L.D. and Christodoulou, John (2013) Protein folding on the ribosome studied using NMR spectroscopy. Progress in Nuclear Magnetic Resonance Spectroscopy 74 , pp. 57-75. ISSN 0079-6565.

November 2013

Clare, Daniel K. and Saibil, Helen R. (2013) ATP-driven molecular chaperone machines. Biopolymers 99 (11), pp. 846-859. ISSN 0006-3525.

15 November 2013

Gouge, Jerome and Rosario, S. and Romain, F. and Beguin, P. and Delarue, M. (2013) Structures of intermediates along the catalytic cycle of terminal deoxynucleotidyltransferase: dynamical aspects of the two-metal ion mechanism. Journal of Molecular Biology 425 (22), pp. 4334-52. ISSN 0022-2836.

29 November 2013

Randall, T.S. and Moores, Carolyn A. and Stephenson, F.A. (2013) Delineation of the TRAK binding regions of the kinesin-1 motor proteins. FEBS Letters 587 (23), pp. 3763-3769. ISSN 1873-3468.

December 2013

Ganser, L.R. and Yan, Q. and James, Victoria M. and Kozol, R. and Topf, Maya and Harvey, R.J. and Dallman, J.E. (2013) Distinct phenotypes in zebrafish models of human startle disease. Neurobiology of Disease 60 , pp. 139-151. ISSN 0969-9961.

Shiu, W.K.P. and Malkinson, J.P. and Rahman, M.M. and Curry, J. and Stapleton, P. and Gunaratnam, M. and Neidle, S. and Mushtaq, S. and Warner, M. and Livermore, D.M. and Evangelopoulos, Dimitrios and Basavannacharya, Chandrakala and Bhakta, Sanjib and Schindler, B.D. and Seo, S.M. and Coleman, D. and Kaatz, G.W. and Gibbons, S. (2013) A new plant-derived antibacterial is an inhibitor of efflux pumps in Staphylococcus aureus. International Journal of Antimicrobial Agents 42 (6), pp. 513-518. ISSN 0924-8579.

18 December 2013

Hofmann, A. and Garcia, A.F. and Lopes, J.L.S. and Costa-Filho, A.J. and Wallace, Bonnie A. and Araujo, A.P.U. (2013) Membrane interactions of S100A12 (Calgranulin C). PLoS One 8 (12), e82555. ISSN 1932-6203.

23 December 2013

Ramsey, K. and Dumoux, Maud and Le Gall, S.M. and Habbeddine, M. and Delarbre, C. and Hayward, Richard D. and Kanellopoulos-Langevin, C. and Verbeke, P. (2013) Penicillin kills chlamydia following the fusion of bacteria with Lysosomes and prevents genital inflammatory lesions in C. muridarum-infected mice. PLoS One 8 (12), e83511. ISSN 1932-6203.

30 December 2013

Zihni, C. and Munro, P.M.G. and Elbediwy, A. and Keep, Nicholas H. and Terry, S.J. and Harris, J. and Balda, M.S. and Matter, K. (2013) Dbl3 drives Cdc42 signaling at the apical margin to regulate junction position and apical differentiation. The Journal of Cell Biology 204 (1), pp. 111-127. ISSN 0021-9525.