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    Number of items: 82.

    Acta Crystallographica Section D Biological Crystallography

    Wood, C. and Burnley, T. and Patwardhan, A. and Scheres, S. and Topf, Maya and Roseman, A. and Winn, M. (2015) Collaborative computational project for electron cryo-microscopy. Acta Crystallographica Section D Biological Crystallography 71 (1), pp. 123-126. ISSN 1399-0047.

    Acta Crystallographica Section D: Structural Biology

    Cragnolini, Tristan and Sahota, Harpal and Joseph, Agnel Praveen and Sweeney, Aaron and Malhotra, Sony and Vasishtan, D. and Topf, Maya (2021) TEMPy2: a Python library with improved 3D electron microscopy density-fitting and validation workflows. Acta Crystallographica Section D: Structural Biology 77 (1), pp. 41-47. ISSN 2059-7983.

    Animal Genetics

    Gill, J.L. and James, Victoria M. and Carta, E. and Harris, D. and Topf, Maya and Scholes, S.F.E. and Hateley, G. and Harvey, R.J. (2012) Identification of congenital muscular dystonia 2 associated with an inherited GlyT2 defect in Belgian Blue cattle from the United Kingdom. Animal Genetics 43 (3), pp. 267-270. ISSN 0268-9146.

    Annual Review of Biochemistry

    Alber, F. and Forster, F. and Korkin, D. and Topf, Maya and Sali, A. (2008) Integrating diverse data for structure determination of macromolecular assemblies. Annual Review of Biochemistry 77 , pp. 443-477. ISSN 0066-4154.

    Biochemistry

    Yuan, Shujun and Topf, Maya and Reubold, T.F. and Eschenburg, S. and Akey, C.W. (2013) Changes in Apaf-1 conformation that drive apoptosome assembly. Biochemistry 52 (13), pp. 2319-2327. ISSN 0006-2960.

    Bioinformatics

    Bullock, Joshua and Thalassinos, Konstantinos and Topf, Maya (2018) Jwalk and MNXL web server: model validation using restraints from Crosslinking Mass Spectrometry. Bioinformatics 34 (20), pp. 3584-3585. ISSN 1367-4803.

    Pandurangan, Arun and Topf, Maya (2012) RIBFIND: a web server for identifying rigid bodies in protein structures and to aid flexible fitting into cryo EM maps. Bioinformatics 28 (18), pp. 2391-2393. ISSN 1367-4803.

    Zhang, S.H. and Vasishtan, Daven and Xu, M. and Topf, Maya and Alber, F. (2010) A fast mathematical programming procedure for simultaneous fitting of assembly components into cryoEM density maps. Bioinformatics 26 (12), i261-i268. ISSN 1367-4803.

    Rawi, R. and Whitmore, Lee and Topf, Maya (2010) CHOYCE: a web server for constrained homology modelling with cryoEM maps. Bioinformatics 26 (13), pp. 1673-1674. ISSN 1367-4803.

    Brain

    Cif, L. and Demailly, D. and Lin, J.-P. and Barwick, K.E. and Sa, M. and Abela, L. and Malhotra, S. and Chong, W.K. and Steel, D. and Sanchis-Juan, A. and Ngoh, A. and Trump, N. and Meyer, E. and Vasques, X. and Rankin, J. and Allain, M.W. and Applegate, C.D. and Attaripour Isfahani, S. and Baleine, J. and Balint, B. and Bassetti, J.A. and Baple, E.L. and Bhatia, K.P. and Blanchet, C. and Burglen, L. and Cambonie, G. and Seng, E.C. and Bastaraud, S.C. and Cyprien, F. and Coubes, C. and d’Hardemare, V. and Doja, A. and Dorison, N. and Doummar, D. and Dy-Hollins, M.E. and Farrelly, E. and Fitzpatrick, D.R. and Fearon, C. and Fieg, E.L. and Fogel, B.L. and Forman, E.B. and Fox, R.G. and Gahl, W.A. and Galosi, S. and Gonzalez, V. and Graves, T.D. and Gregory, A. and Hallett, M. and Hasegawa, H. and Hayflick, S.J. and Hamosh, A. and Hully, M. and Jansen, S. and Jeong, S.Y. and Krier, J.B. and Krystal, S. and Kumar, K.R. and Laurencin, C. and Lee, H. and Lesca, G. and François, L.L. and Lynch, T. and Mahant, N. and Martinez-Agosto, J.A. and Milesi, C. and Mills, K.A. and Mondain, M. and Morales-Briceno, H. and Ostergaard, J.R and Pal, S. and Pallais, J.C. and Pavillard, F. and Perrigault, P.-F. and Petersen, A.K. and Polo, G. and Poulen, G. and Rinne, T. and Roujeau, T. and Rogers, C. and Roubertie, A. and Sahagian, M. and Schaefer, E. and Selim, L. and Selway, R. and Sharma, N. and Signer, R. and Soldatos, A.G. and Stevenson, D.A. and Stewart, F. and Tchan, M. and Verma, I.C. and de Vries, B.B.A and Wilson, J.L. and Wong, D.A. and Zaitoun, R. and Zhen, D. and Znaczko, A. and Dale, R.C. and de Gusmão, C.M. and Friedman, J. and Fung, V.S.C. and King, M.D. and Mohammad, S.S and Rohena, L. and Waugh, J.L. and Toro, C. and Raymond, F.L. and Topf, Maya and Coubes, P. and Gorman, K.M. and Kurian, M.A. (2020) KMT2B-related disorders: expansion of the phenotypic spectrum and long-term efficacy of deep brain stimulation. Brain , ISSN 0006-8950. (In Press)

    Cell

    Clare, Daniel K. and Vasishtan, Daven and Stagg, S. and Quispe, J. and Farr, G.W. and Topf, Maya and Horwich, A.L. and Saibil, Helen R. (2012) ATP-triggered conformational changes delineate substrate-binding and -folding mechanics of the GroEL Chaperonin. Cell 149 (1), pp. 113-123. ISSN 0092-8674.

    Chemistry: A European Journal

    Pereira, R. and Gendron, T. and Sanghera, C. and Greenwood, H.E. and Newcombe, J. and McCormick, P.N. and Sander, K. and Topf, Maya and Arstad, E. and Witney, T.H. (2019) Mapping Aldehyde Dehydrogenase 1A1 activity using an [18F]Substrate-based approach. Chemistry: A European Journal , ISSN 0947-6539. (In Press)

    Current Opinion in Structural Biology

    Joseph, Agnel Praveen and Polles, G. and Alber, F. and Topf, Maya (2017) Integrative modelling of cellular assemblies. Current Opinion in Structural Biology 46 , pp. 102-109. ISSN 0959-440X.

    EMBO Reports

    Malet, Hélène and Topf, Maya and Clare, Daniel K. and Ebert, J. and Bonneau, F. and Basquin, J. and Drazkowska, K. and Tomecki, R. and Dziembowski, A. and Conti, E. and Saibil, Helen R. and Lorentzen, Esben (2010) RNA channelling by the eukaryotic exosome. EMBO Reports 11 (12), pp. 936-942. ISSN 1469-221X.

    Frontiers in Molecular Neuroscience

    Kalscheuer, V.M. and James, V.M. and Himelright, M.L. and Long, P. and Oegema, R. and Jensen, C. and Bienek, M. and Hu, H. and Haas, S.A. and Topf, Maya and Hoogeboom, A.J.M. and Harvey, K. and Walikonis, R. and Harvey, R.J. (2016) Novel Missense Mutation A789V in IQSEC2 underlies X-Linked intellectual disability in the MRX78 family. Frontiers in Molecular Neuroscience 8 , ISSN 1662-5099.

    Human Molecular Genetics

    Demetriou, C. and Chanudet, E. and Joseph, Agnel and Topf, Maya and Thomas, A.C. and Bitner-Glindzicz, M. and Regan, L. and Stanier, P. and Moore, G.E. (2019) Exome sequencing identifies variants in FKBP4 that are associated with recurrent fetal loss in humans. Human Molecular Genetics , ISSN 0964-6906. (In Press)

    Kumar, R.A. and Pilz, D.T. and Babatz, T.D. and Cushion, T.D. and Harvey, K. and Topf, Maya and Yates, L. and Robb, S. and Uyanik, G. and Mancini, G.M.S. and Rees, M.I. and Harvey, R.J. and Dobyns, W.B. (2010) TUBA1A mutations cause wide spectrum lissencephaly (smooth brain) and suggest that multiple neuronal migration pathways converge on alpha tubulins. Human Molecular Genetics 19 (14), pp. 2817-2827. ISSN 0964-6906.

    Journal of Applied Crystallography

    Farabella, I. and Vasishtan, D. and Joseph, Agnel Praveen and Pandurangan, Arun Prasad and Sahota, Harpal and Topf, Maya (2015) TEMPy: a Python library for assessment of 3D electron microscopy density fits. Journal of Applied Crystallography 48 , pp. 1314-1323. ISSN 0021-8898.

    Journal of Biological Chemistry

    Cook, Alex and Roberts, Anthony J. and Atherton, Joe and Tewari, R. and Topf, Maya and Moores, Carolyn A. (2021) Cryo-EM structure of a microtubule-bound parasite kinesin motor and implications for its mechanism and inhibition. Journal of Biological Chemistry 297 (5), p. 101063. ISSN 0021-9258.

    Gartmann, M. and Blau, M. and Armache, J. P. and Mielke, T. and Topf, Maya and Beckmann, R. (2010) Mechanism of eIF6-mediated inhibition of ribosomal subunit joining. Journal of Biological Chemistry 285 (20), pp. 14848-14851. ISSN 0021-9258.

    Journal of Clinical Investigation

    Al-Olabi, L. and Polubothu, S. and Dowsett, K. and Andrews, K.A. and Stadnik, P. and Joseph, A.P. and Knox, R. and Pittman, A. and Clark, G. and Baird, W. and Bulstrode, N. and Glover, M. and Gordon, K. and Hargrave, D. and Huson, S.M. and Jacques, T.S. and James, G. and Kondolf, H. and Kangesu, L. and Keppler-Noreuil, K.M. and Khan, A. and Lindhurst, M.J. and Lipson, M. and Mansour, S. and O’Hara, J. and Mahon, C. and Mosica, A. and Moss, C. and Murthy, A. and Ong, J. and Parker, V.E. and Rivière, J.-B. and Sapp, J.C. and Sebire, N.J. and Shah, R. and Sivakumar, B. and Thomas, A. and Virasami, A. and Waelchli, R. and Zeng, Z. and Biesecker, L.G. and Barnacle, A. and Topf, Maya and Semple, R.K. and Patton, E.E. and Kinsler, V.A. (2018) Mosaic RAS/MAPK variants cause sporadic vascular malformations which respond to targeted therapy. Journal of Clinical Investigation 128 (4), pp. 1496-1508. ISSN 0021-9738.

    Journal of Molecular Biology

    Lasker, K. and Topf, Maya and Sali, A. and Wolfson, H.J. (2009) Inferential optimization for simultaneous fitting of multiple components into a CryoEM map of their assembly. Journal of Molecular Biology 388 (1), pp. 180-184. ISSN 0022-2836.

    Cong, Y. and Topf, Maya and Sali, A. and Matsudaira, P. and Dougherty, M. and Chiu, W. and Schmid, M.F. (2008) Crystallographic conformers of Actin in a biologically active bundle of filaments. Journal of Molecular Biology 375 (2), pp. 331-336. ISSN 0022-2836.

    Journal of Structural Biology

    Joseph, Agnell Praveen and Lagerstedt, I. and Patwardhan, A. and Topf, Maya and Winn, M. (2017) Improved metrics for comparing structures of macromolecular assemblies determined by 3D electron-microscopy. Journal of Structural Biology 199 (1), pp. 12-26. ISSN 1047-8477.

    Pandurangan, A.P. and Shakeel, S. and Butcher, S. and Topf, Maya (2013) Combined approaches to flexible fitting and assessment in virus capsids undergoing conformational change. Journal of Structural Biology 185 (3), pp. 427-439. ISSN 1047-8477.

    Pandurangan, Arun and Topf, Maya (2012) Finding rigid bodies in protein structures: application to flexible fitting into cryoEM maps. Journal of Structural Biology 177 (2), pp. 520-531. ISSN 1047-8477.

    Vasishtan, Daven and Topf, Maya (2011) Scoring functions for cryoEM density fitting. Journal of Structural Biology 174 (2), pp. 333-343. ISSN 1047-8477.

    Beck, M. and Topf, Maya and Frazier, Z. and Tjong, H. and Xu, M. and Zhang, S.H. and Alber, F. (2011) Exploring the spatial and temporal organization of a cell's proteome. Journal of Structural Biology 173 (3), pp. 483-496. ISSN 1047-8477.

    Journal of the American Chemical Society

    Wright, Z.V.F. and McCarthy, S. and Dickman, R. and Reyes, F.E. and Sanchez-Martinez, S. and Cryar, Adam and Kilford, I. and Hall, A. and Takle, A.K. and Topf, Maya and Gonen, T. and Thalassinos, Konstantinos and Tabor, A.B. (2017) The role of disulfide bond replacements in analogues of the Tarantula toxin ProTx-II and their effects on inhibition of the voltage-gated sodium ion channel Nav1.7. Journal of the American Chemical Society 139 (37), pp. 13063-13075. ISSN 0002-7863.

    Methods

    Beton, Joseph and Moorehead, R. and Helfmann, L. and Gray, R. and Hoogenboom, B.W. and Praveen Joseph, Agnel and Topf, Maya and Pyne, A.L.B. (2021) TopoStats – a program for automated tracing of biomolecules from AFM images. Methods , ISSN 1046-2023. (In Press)

    Joseph, Agnel Praveen and Malhotra, S. and Burnley, T. and Wood, C. and Clare, D.K. and Winn, M. and Topf, Maya (2016) Refinement of atomic models in high resolution EM reconstructions using Flex-EM and local assessment. Methods 100 , pp. 42-49. ISSN 1046-2023.

    Molecular & Cellular Proteomics

    Ashford, Paul and Hernandez duran, Anna and Greco, T.M. and Buch, A. and Sodeik, B. and Cristea, I.M. and Grünewald, K. and Shepherd, Adrian J. and Topf, Maya (2016) HVint: a strategy for identifying novel protein-protein interactions in Herpes Simplex Virus Type 1. Molecular & Cellular Proteomics 15 (9), pp. 2939-2953. ISSN 1535-9476.

    Bullock, Joshua and Schwab, J. and Thalassinos, Konstantinos and Topf, Maya (2016) The importance of non-accessible crosslinks and solvent accessible surface distance in modelling proteins with restraints from crosslinking mass spectrometry. Molecular & Cellular Proteomics 15 (7), pp. 2491-2500. ISSN 1535-9476.

    Molecular Microbiology

    Redzej, Adam and Ilangovan, Aravindan and Lang, S. and Gruber, C.J. and Topf, Maya and Zangger, K. and Zechner, E.L. and Waksman, Gabriel (2013) Structure of a translocation signal domain mediating conjugative transfer by Type IV secretion systems. Molecular Microbiology 89 (2), pp. 324-333. ISSN 0950-382X.

    Molecular Pharmacology

    Newcombe, J. and Chatzidaki, A. and Sheppard, T.D. and Topf, Maya and Millar, N.S. (2017) Diversity of nicotinic acetylcholine receptor positive allosteric modulators revealed by mutagenesis and a revised structural model. Molecular Pharmacology 93 (2), pp. 128-140. ISSN 0026-895X.

    Molecular Psychiatry

    Pilorge, M. and Fassier, C. and Le Corronc, H. and Potey, A. and Bai, J. and De Gois, S. and Delaby, E. and Assouline, B. and Guinchat, V. and Devillard, F. and Delorme, R. and Nygren, G. and Råstam, M. and Meier, J.C. and Otani, S. and Cheval, H. and James, V.M. and Topf, Maya and Dear, T.N. and Gillberg, C. and Leboyer, M. and Giros, B. and Gautron, S. and Hazan, J. and Harvey, R.J. and Legendre, P. and Betancur, C. (2016) Genetic and functional analyses demonstrate a role for abnormal glycinergic signaling in autism. Molecular Psychiatry 21 , pp. 936-945. ISSN 1359-4184.

    Movement Disorders

    Carecchio, Miryam and Invernizzi, F. and Gonzàlez-Latapi, P. and Panteghini, C. and Zorzi, G. and Romito, L. and Leuzzi, V. and Galosi, S. and Reale, C. and Zibordi, F. and Joseph, A.P. and Topf, Maya and Piano, C. and Bentivoglio, A.R. and Girotti, F. and Morana, P. and Morana, B. and Kurian, M.A. and Garavaglia, B. and Mencacci, N.E. and Lubbe, S.J. and Nardocci, N. (2019) Frequency and phenotypic spectrum of KMT2B dystonia in childhood: A single‐center cohort study. Movement Disorders , ISSN 0885-3185. (In Press)

    Nature Communications

    Topf, Maya (2021) Assessment of protein-protein interfaces in cryo-EM derived assemblies. Nature Communications 12 (3399), ISSN 2041-1723.

    Ignatiou, I. and Brasilès, S. and El Sadek Fadel, M. and Bürger, J. and Mielke, T. and Topf, Maya and Tavares, P. and Orlova, Elena (2019) Structural transitions during the scaffolding-driven assembly of a viral capsid. Nature Communications 10 , p. 4840. ISSN 2041-1723.

    Menny, A. and Serna, M. and Boyd, C.M. and Gardner, S. and Joseph, A.P. and Morgan, B.P. and Topf, Maya and Brooks, N.J. and Bubeck, D. (2018) CryoEM reveals how the complement membrane attack complex ruptures lipid bilayers. Nature Communications 9 (1), ISSN 2041-1723.

    Fedele, L. and Newcombe, J. and Topf, Maya and Gibb, A. and Harvey, R.J. and Smart, T.G. (2018) Disease-associated missense mutations in GluN2B subunit alter NMDA receptor ligand binding and ion channel properties. Nature Communications 9 (1), p. 957. ISSN 2041-1723.

    Stödberg, T. and McTague, A. and Ruiz, A.J. and Hirata, H. and Zhen, J. and Long, P. and Farabella, Irene and Meyer, E. and Kawahara, A. and Vassallo, G. and Stivaros, S.M. and Bjursell, M.K. and Stranneheim, H. and Tigerschiöld, S. and Persson, B. and Bangash, I. and Das, K. and Hughes, D. and Lesko, N. and Lundeberg, J. and Scott, R.C. and Poduri, A. and Scheffer, I.E. and Smith, H. and Gissen, P. and Schorge, S. and Reith, M.E.A. and Topf, Maya and Kullmann, D.M. and Harvey, R.J. and Wedell, A. and Kurian, M.A. (2015) Mutations in SLC12A5 in epilepsy of infancy with migrating focal seizures. Nature Communications 6 , p. 8038. ISSN 2041-1723.

    Mortensen, M. and Iqbal, F. and Pandurangan, Arun and Hannan, S. and Huckvale, R. and Topf, Maya and Baker, J.R. and Smart, T.G. (2014) Photo-antagonism of the GABAA receptor. Nature Communications 5 , ISSN 2041-1723.

    Nature Genetics

    Meyer, E. and Carss, K.J and Rankin, J. and Nichols, J.M.E and Grozeva, D. and Joseph, A.P and Mencacci, N.E. and Papandreou, A. and Ng, J. and Barral, S. and Ngoh, A. and Ben-Pazi, H. and Willemsen, M.A. and Arkadir, D. and Barnicoat, A. and Bergman, H. and Bhate, S. and Boys, A. and Darin, N. and Foulds, N. and Gutowski, N. and Hills, A. and Houlden, H. and Hurst, J.A. and Israel, Z. and Kaminska, M. and Limousin, P. and Lumsden, D. and McKee, S. and Misra, S. and Mohammed, S.S. and Nakou, V. and Nicolai, J. and Nilsson, M. and Pall, H. and Peall, K.J. and Peters, G.B. and Prabhakar, P. and Reuter, M.S. and Rump, P. and Segel, R. and Sinnema, M. and Smith, M. and Turnpenny, P. and White, S.M. and Wieczorek, D. and Wiethoff, S. and Wilson, B.T. and Winter, G. and Wragg, C. and Pope, S. and Heales, S.J.H. and Morrogh, D. and Pittman, A. and Carr, L. J. and Perez-Dueñas, B. and Lin, J.-P. and Reis, A. and Gahl, W.A. and Toro, C. and Bhatia, K.P. and Wood, N.W. and Kamsteeg, E.-J. and Chong, W.K. and Gissen, P. and Topf, Maya and Dale, R.C. and Chubb, J.R. and Raymond, F.L. and Kurian, M.A. (2016) Mutations in the histone methyltransferase gene KMT2B cause complex early-onset dystonia. Nature Genetics 49 , pp. 223-237. ISSN 1061-4036.

    Nature Structural & Molecular Biology

    Miller, P.S. and Topf, Maya and Smart, T.G. (2008) Mapping a molecular link between allosteric inhibition and activation of the glycine receptor. Nature Structural & Molecular Biology 15 , pp. 1084-1093. ISSN 1545-9985.

    Connell, S.R. and Topf, Maya and Qin, Y. and Wilson, D.N. and Mielke, T. and Fucini, P. and Nierhaus, K.H. and Spahn, C.M.T. (2008) A new tRNA intermediate revealed on the ribosome during EF4-mediated back-translocation. Nature Structural & Molecular Biology 15 , pp. 910-915. ISSN 1545-9985.

    Nature Structural and Molecular Biology

    Atherton, Joe and Jiang, K. and Stangier, M.M. and Luo, Y. and Hua, S. and Houben, K. and von Hooff, J.J.E. and Joseph, Agnel Praveen and Scarabelli, G. and Grant, B.J. and Roberts, Anthony and Topf, Maya and Steinmetz, M. and Baldus, M. and Moores, Carolyn A. and Akhmanova, A. (2017) A structural model for microtubule minus-end recognition and protection by CAMSAP proteins. Nature Structural and Molecular Biology 24 , pp. 931-943. ISSN 1545-9993.

    Booth, C.R. and Meyer, A.S. and Cong, Y. and Topf, Maya and Sali, A. and Ludtke, Steven J. and Chiu, W. and Frydman, J. (2008) Mechanism of lid closure in the eukaryotic chaperonin TRiC/CCT. Nature Structural and Molecular Biology 15 (7), pp. 746-753. ISSN 1545-9993.

    Neurobiology of Disease

    Ganser, L.R. and Yan, Q. and James, Victoria M. and Kozol, R. and Topf, Maya and Harvey, R.J. and Dallman, J.E. (2013) Distinct phenotypes in zebrafish models of human startle disease. Neurobiology of Disease 60 , pp. 139-151. ISSN 0969-9961.

    James, Victoria M. and Bode, A. and Chung, S.-K. and Gill, J.L. and Nielsen, M. and Cowan, Frances M. and Vujic, M. and Thomas, R.H. and Rees, M.I. and Harvey, K. and Keramidas, A. and Topf, Maya and Ginjaar, I. and Lynch, J.W. and Harvey, R.J. (2013) Novel missense mutations in the glycine receptor β subunit gene (GLRB) in startle disease. Neurobiology of Disease 52 , pp. 137-149. ISSN 0969-9961.

    Neurology

    McTague, A. and Nair, U. and Malhotra, S. and Meyer, E. and Trump, N. and Gazina, E.V. and Papandreou, A. and Ngoh, A. and Ackermann, S. and Ambegaonkar, G. and Appleton, R. and Desurkar, A. and Eltze, C. and Kneen, R. and Kumar, A.V. and Lascelles, K. and Montgomery, T. and Ramesh, V. and Samanta, R. and Scott, R.H. and Tan, J. and Whitehouse, W. and Poduri, A. and Scheffer, I.E. and Chong, W.K. and Cross, J.H. and Topf, Maya and Petrou, S. and Kurian, M.A. (2018) Clinical and molecular characterization ofKCNT1-related severe early-onset epilepsy. Neurology 90 (1), ISSN 0028-3878.

    McTague, A. and Nair, U. and Malhotra, S. and Meyer, E. and Trump, N. and Gazina, E.V. and Papandreou, A. and Ngoh, A. and Ackermann, S. and Ambegaonkar, G. and Appleton, R. and Desurkar, A. and Eltze, C. and Kneen, R. and Kumar, A.V. and Lascelles, K. and Montgomery, T. and Ramesh, V. and Samanta, R. and Scott, R.H. and Tan, J. and Whitehouse, W. and Poduri, A. and Scheffer, I.E. and Chong, W.K. "Kling" and Cross, H.K. and Topf, Maya and Petrou, S. and Kurian, M.A. (2017) Clinical and molecular characterisation of KCNT1-related severe early onset epilepsy. Neurology 90 (1), ISSN 0028-3878.

    Neuropharmacology

    Smelt, C.L.C. and Sanders, V.R. and Newcombe, J. and Burt, R.P. and Sheppard, T.D. and Topf, Maya and Millar, N.S. (2018) Identification by virtual screening and functional characterisation of novel positive and negative allosteric modulators of the α7 nicotinic acetylcholine receptor. Neuropharmacology 139 , pp. 194-204. ISSN 0028-3908.

    PLoS Biology

    Bhella, D. and Hernández Durán, A. and Greco, T.M. and Vollmer, B. and Cristea, I.M. and Grünewald, K. and Topf, Maya (2019) Protein interactions and consensus clustering analysis uncover insights into herpesvirus virion structure and function relationships. PLoS Biology 17 (6), e3000316. ISSN 1545-7885.

    Lukoyanova, Natalya and Kondos, S.C. and Farabella, Irene and Law, R.H.P. and Reboul, C.F. and Caradoc-Davies, T.T. and Spicer, B.A. and Kleifeld, O. and Traore, D.A.K. and Ekkel, S.M. and Voskoboinik, I. and Trapani, J.A. and Hatfaludi, T. and Oliver, K. and Hotze, E.M. and Tweten, R.K. and Whisstock, J.C. and Topf, Maya and Saibil, Helen R. and Dunstone, M.A. (2015) Conformational changes during pore formation by the perforin-related protein pleurotolysin. PLoS Biology 13 (2), e1002049. ISSN 1545-7885.

    Proceedings of the National Academy of Sciences of the United States of America

    Locke, Julia and Joseph, Agnel Praveen and Pena, Alejandro and Mockel, M. and Mayer, T. and Topf, Maya and Moores, Carolyn A. (2017) Structural basis of human kinesin-8 function and inhibition. Proceedings of the National Academy of Sciences of the United States of America 114 (45), E9539-E9548. ISSN 0027-8424.

    Zeev-Ben-Mordehai, T. and Vasishtan, D. and Hernández Durán, A. and Vollmer, B. and White, P. and Prasad Pandurangan, A. and Siebert, C.A. and Topf, Maya and Grünewald, K. (2016) Two distinct trimeric conformations of natively membrane-anchored full-length herpes simplex virus 1 glycoprotein B. Proceedings of the National Academy of Sciences of the United States of America 113 (15), pp. 4176-4181. ISSN 0027-8424.

    Serysheva, I.I. and Baker, M.L. and Cong, Y. and Topf, Maya and Eramian, D. and Sali, A. and Hamilton, S.L. and Chiu, W. (2008) Subnanometer-resolution electron cryomicroscopy-based domain models for the cytoplasmic region of skeletal muscle RyR channel. Proceedings of the National Academy of Sciences of the United States of America 105 (28), pp. 9610-9615. ISSN 0027-8424.

    Proteins: Structure, Function, and Bioinformatics

    Kryshtafovych, A. and Schwede, T. and Topf, Maya and Fidelis, K. and Moult, J. (2019) Critical assessment of methods of Protein Structure Prediction (CASP) – Round XIII. Proteins: Structure, Function, and Bioinformatics 87 (12), pp. 1011-1020. ISSN 0887-3585.

    Kryshtafovych, A. and Malhotra, Sony and Monastyrskyy, B. and Cragnolini, T. and Joseph, A.‐P. and Chiu, W. and Topf, Maya (2019) Cryo‐EM targets in CASP13: overview and evaluation of results. Proteins: Structure, Function, and Bioinformatics , ISSN 0887-3585. (In Press)

    Lepore, R. and Kryshtafovych, A. and Alahuhta, M. and Veraszto, H.A. and Bomble, Y. J. and Bufton, J.C. and Bullock, A.N. and Caba, C. and Cao, H. and Davies, O.R. and Desfosses, A. and Dunne, M. and Fidelis, K. and Goulding, C.W. and Gurusaran, M. and Gutsche, I. and Harding, C.J. and Hartmann, M.D. and Hayes, C.S. and Joachimiak, A. and Leiman, P.G. and Loppnau, P. and Lovering, A.L. and Lunin, V.V. and Michalska, K. and Mir‐Sanchis, I. and Mitra, A. and Moult, J. and Phillips Jr, G.N. and Pinkas, D.M. and Rice, P.A. and Tong, Y. and Topf, Maya and Walton, J.D. and Schwede, T. (2019) Target highlights in CASP13: experimental target structures through the eyes of their authors. Proteins: Structure, Function, and Bioinformatics , ISSN 0887-3585.

    Science Advances

    Vollmer, B. and Pražák, V. and Vasishtan, D. and Jefferys, E.E. and Hernandez-Duran, A. and Vallbracht, M. and Klupp, B. and Mettenleiter, T.C. and Backovic, M. and Rey, F.A. and Topf, Maya and Grünewald, K. (2020) The pre-fusion structure of Herpes simplex virus glycoprotein B. Science Advances 6 (39), ISSN 2375-2548.

    Deville, Celia and Carroni, Marta and Franke, K.B. and Topf, Maya and Bukau, B. and Mogk, A. and Saibil, Helen R. (2017) Structural pathway of regulated substrate transfer and threading through an Hsp100 disaggregase. Science Advances 3 (8), e1701726. ISSN 2375-2548.

    Structure

    Peña, A. and Sweeney, A. and Cook, A.D. and Topf, Maya and Moores, Carolyn A. (2020) Structure of microtubule-trapped Human Kinesin-5 and its mechanism of inhibition revealed using Cryoelectron Microscopy. Structure 28 (4), pp. 450-457. ISSN 0969-2126.

    Bullock, Joshua M.A. and Sen, N. and Thalassinos, Konstantinos and Topf, Maya (2018) Modeling protein complexes using restraints from Crosslinking Mass Spectrometry. Structure 26 (7), 1015-1024.e2. ISSN 0969-2126.

    Pandurangan, Arun and Vasishtan, D. and Alber, F. and Topf, Maya (2015) γ-TEMPy: simultaneous fitting of components in 3D-EM maps of their assembly using a genetic algorithm. Structure 23 (12), pp. 2365-2376. ISSN 0969-2126.

    Sali, A. and Berman, H.M. and Schwede, T. and Trewhella, J. and Kleywegt, G. and Burley, S.K. and Markley, J. and Nakamura, H. and Adams, P. and Bonvin, A.M.J.J. and Wah, C. and Dal Peraro, M. and Di Maio, F. and Ferrin, T.E. and Grünewald, K. and Gutmanas, A. and Henderson, R. and Hummer, G. and Iawsaki, K. and Johnson, G. and Lawson, C.L. and Meiler, J. and Marti-Renom, M.A. and Montelione, G.T. and Nilges, M. and Nussinov, R. and Patwardhan, A. and Rappsilber, J. and Read, R.J. and Saibil, Helen R. and Schröder, G.F. and Schwieters, C. and Seidel, C.A.M. and Svergun, D. and Topf, Maya and Ulrich, E.L. and Velankar, S. and Westbrook, J.D. (2015) Outcome of the First wwPDB Hybrid / Integrative Methods Task Force Workshop. Structure 23 (7), pp. 1156-1167. ISSN 0969-2126.

    Thalassinos, Konstantinos and Pandurangan, Arun and Xu, M. and Alber, F. and Topf, Maya (2013) Conformational states of macromolecular assemblies explored by integrative structure calculation. Structure 21 (9), pp. 1500-1508. ISSN 0969-2126.

    Maurer, U.E. and Zeev-Ben-Mordehai, T. and Pandurangan, Arun and Cairns, T.M. and Hannah, B.P. and Whitbeck, J.C. and Eisenberg, R.J. and Cohen, G.H. and Topf, Maya and Huiskonen, J.T. and Grünewald, K. (2013) The structure of Herpesvirus Fusion Glycoprotein B-Bilayer Complex reveals the protein-membrane and lateral protein-protein interaction. Structure 21 (8), pp. 1396-1405. ISSN 0969-2126.

    Yuan, Shujun and Yu, Xinchao and Topf, Maya and Dorstyn, Loretta and Kumar, Sharad and Ludtke, Steven J. and Akey, C.W. (2011) Structure of the Drosophila Apoptosome at 6.9 Å Resolution. Structure 19 (1), pp. 128-140. ISSN 09692126.

    Taylor, D.J. and Devkota, B. and Huang, A.D. and Topf, Maya and Narayanan, E. and Sali, A. and Harvey, S.C. and Frank, J. (2009) Comprehensive molecular structure of the Eukaryotic Ribosome. Structure 17 (12), pp. 1591-1604. ISSN 0969-2126.

    Chandramouli, P. and Topf, Maya and Menetret, J.F. and Eswar, N. and Cannone, J.J. and Gutell, R.R. and Sali, A. and Akey, C.W. (2008) Structure of the mammalian 80S ribosome at 87 angstrom resolution. Structure 16 (4), pp. 535-548. ISSN 0969-2126.

    Topf, Maya and Lasker, K. and Webb, B. and Wolfson, H.J. and Chiu, W. and Sali, A. (2008) Protein structure fitting and refinement guided by cryo-EM density. Structure 16 (2), pp. 295-307. ISSN 0969-2126.

    The Journal of Neuroscience

    Schaefer, N. and Berger, A. and van Brederode, J. and Zheng, F. and Zhang, Y. and Leacock, S. and Littau, L. and Jablonka, S. and Malhotra, S. and Topf, Maya and Winter, F. and Davydova, D. and Lynch, J.W. and Paige, C.J. and Alzheimer, C. and Harvey, R.J. and Villmann, C. (2017) Disruption of a structurally important extracellular element in the Glycine Receptor leads to decreased synaptic integration and signaling resulting in Severe Startle Disease. The Journal of Neuroscience 37 (33), pp. 7948-7961. ISSN 0270-6474.

    Trends in Genetics

    Harvey, R.J. and Topf, Maya and Harvey, K. and Rees, M.I. (2008) The genetics of hyperekplexia: more than startle! Trends in Genetics 24 (9), pp. 439-447. ISSN 0168-9525.

    Viruses

    Tweedy, J. and Escriva, E. and Topf, Maya and Gompels, U. (2017) Analyses of tissue culture adaptation of human Herpesvirus-6A by whole genome deep sequencing redefines the reference sequence and identifies virus entry complex changes. Viruses 10 (1), p. 16. ISSN 1999-4915.

    eLife

    Fumagalli, M. and Camus, S.M. and Diekmann, Y. and Burke, A. and Camus, M.D. and Norman, P.J. and Joseph, A. and Abi-Rached, L. and Benazzo, A. and Rasteiro, R. and Mathieson, I. and Topf, Maya and Parham, P. and Thomas, M.G. and Brodsky, F.M. (2019) Genetic diversity of CHC22 clathrin impacts its function in glucose metabolism. eLife 8 , e41517. ISSN 2050-084X.

    Atherton, Joseph and Yu, I-M. and Cook, Alexander and Muretta, J. and Joseph, Agnel Praveen and Major, J. and Sourigues, Y. and Clause, J. and Topf, Maya and Rosenfeld, S. and Houdusse, A. and Moores, Carolyn A. (2017) The divergent mitotic kinesin MKLP2 exhibits atypical structure and mechanochemistry. eLife , ISSN 2050-084X.

    Leung, C. and Dudkina, N.V. and Lukoyanova, Natalya and Hodel, A.W. and Farabella, I. and Pandurangan, A.P. and Jahan, N. and Pires Damaso, M. and Osmanović, D. and Reboul, C.F. and Dunstone, M.A. and Andrew, P.W. and Lonnen, R. and Topf, Maya and Saibil, Helen R. and Hoogenboom, B.W. (2014) Stepwise visualization of membrane pore formation by suilysin, a bacterial cholesterol-dependent cytolysin. eLife 3 , ISSN 2050-084X.

    Farabella, Irene and Pham, T. and Henderson, N.S. and Geibel, Sebastien and Phan, Gilles and Thanassi, D.G. and Delcour, A.H. and Waksman, Gabriel and Topf, Maya (2014) Allosteric signalling in the outer membrane translocation domain of PapC usher. eLife 3 , ISSN 2050-084X.

    Atherton, Joseph and Farabella, Irene and Yu, I-M. and Rosenfeld, S.S. and Houdusse, A. and Topf, Maya and Moores, Carolyn A. (2014) Conserved mechanisms of microtubule-stimulated ADP release, ATP binding, and force generation in transport kinesins. eLife 3 , ISSN 2050-084X.

    mSystems

    Hernández Durán, A. and Grünewald, K. and Topf, Maya and Kristie, T.M. (2019) Conserved Central Intraviral Protein Interactome of the Herpesviridae Family. mSystems 4 (5), e00295-19. ISSN 2379-5077.

    This list was generated on Mon Jan 24 05:41:17 2022 GMT.