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1992
Waksman, Gabriel and Kominos, D. and Robertson, S. and Pant, N. and Baltimore, R. and Birge, D. and Cowburn, H. and Hanafusa, B. and Mayer, B. and Overduin, M. and Resh, M. and Rios, C. and Silverman, L. and Kuriyan, J. (1992) Crystal structure of the phosphotyrosine recognition domain SH2 of v-src complexed with tyrosine-phosphorylated peptides. Nature 358 , pp. 646-653. ISSN 0028-0836.
1993
Waksman, Gabriel and Shoelson, S. and Pant, N. and Cowburn, D. and Kuriyan, J. (1993) Binding of a high affinity phosphotyrosyl peptide to the src SH2 domain: crystal structures of the complexed and peptide-free forms. Cell 72 (5), pp. 779-790. ISSN 0092-8674.
1995
Ornitz, D. and Herr, A. and Nillson, M. and Westman, J. and Svahn, C.-M. and Waksman, Gabriel (1995) FGF binding and FGF receptor activation by synthetic heparan-derived di- and trisaccharides. Science 268 (5209), pp. 432-436. ISSN 0036-8075.
1997
Korolev, S. and Hsieh, J. and Gauss, G.H. and Lohman, T.M. and Waksman, Gabriel (1997) Major domain swiveling revealed by the crystal structures of complexes of e. coli rep helicase bound to single-stranded DNA and ADP. Cell 90 (4), pp. 635-647. ISSN 0092-8674.
1999
Sauer, F.G. and Fütterer, K. and Pinkner, J.S. and Dodson, K.W. and Hultgren, S.J. and Waksman, Gabriel (1999) Structural basis of chaperone function and pilus biogenesis. Science 285 (5430), pp. 1058-1061. ISSN 0036-8075.
2001
Dodson, K.W. and Pinkner, J.S. and Rose, T. and Magnusson, G. and Hultgren, S.J. and Waksman, Gabriel (2001) Structural basis of the interaction of the pyelonephritic e. coli adhesin to its human kidney receptor. Cell 105 (6), pp. 733-743. ISSN 0092-8674.
2002
Sauer, F.G. and Pinkner, J. and Waksman, Gabriel and Hultgren, S.J. (2002) Chaperone priming of pilus subunit facilitates a topological transition that drives fiber formation. Cell 111 (4), pp. 543-551. ISSN 0092-8674.
January 2008
Rose, R.J. and Welsh, T.S. and Waksman, Gabriel and Ashcroft, A.E. and Radford, S.E. and Paci, E. (2008) Donor-strand exchange in chaperone-assisted pilus assembly revealed in atomic detail by molecular dynamics. Journal of Molecular Biology 375 (4), pp. 908-919. ISSN 0022-2836.
March 2008
Allen, William J. and Rothwell, P.J. and Waksman, Gabriel (2008) An intramolecular FRET system monitors fingers subdomain opening in Klentaq1. Protein Science 17 (3), pp. 401-408. ISSN 0961-8368.
May 2008
Remaut, Han and Tang, C. and Henderson, N.S. and Pinkner, J.S. and Wang, T. and Hultgren, S.J. and Thanassi, D.G. and Waksman, Gabriel and Li, H.L. (2008) Fiber formation across the bacterial outer membrane by the chaperone/usher pathway. Cell 133 (4), pp. 640-652. ISSN 0092-8674.
Salih, O. and Remaut, Han and Waksman, Gabriel and Orlova, Elena (2008) Structural analysis of the Saf pilus by electron microscopy and image processing. Journal of Molecular Biology 379 (1), pp. 174-187. ISSN 0022-2836.
June 2008
Bagneris, Claire and Ageichik, A.V. and Cronin, Nora and Wallace, Bonnie A. and Collins, M. and Boshoff, C. and Waksman, Gabriel and Barrett, Tracey E. (2008) Crystal structure of a vFlip-IKK gamma complex: Insights into viral activation of the IKK signalosome. Molecular Cell 30 (5), pp. 620-631. ISSN 1097-2765.
5 June 2008
Bagneris, Claire and Ageichik, A.V. and Cronin, Nora and Wallace, Bonnie A. and Collins, M. and Boshoff, C. and Waksman, Gabriel and Barrett, Tracey E. (2008) Crystal structure of a vFlip-IKKγ Complex: insights into viral activation of the IKK Signalosome. Molecular Cell 30 (5), pp. 620-631. ISSN 1097-2765.
September 2008
Fronzes, Remi and Remaut, Han and Waksman, Gabriel (2008) Architectures and biogenesis of non-flagellar protein appendages in gram-negative bacteria. Embo Journal 27 (17), pp. 2271-2280. ISSN 0261-4189.
de Fabritiis, G. and Geroult, S. and Coveney, P.V. and Waksman, Gabriel (2008) Insights from the energetics binding at the domain-ligand of the Src SH2 domain of water interface. Proteins-Structure, Function and Bioinformatics 72 (4), p. 1290. ISSN 0887-3585.
Rose, R.J. and Verger, Denis and Daviter, Tina and Remaut, Han and Paci, E. and Waksman, Gabriel and Ashcroft, A.E. and Radford, S.E. (2008) Unraveling the molecular basis of subunit specificity in P pilus assembly by mass spectrometry. Proceedings of the National Academy of Sciences of the United States of America 105 (35), pp. 12873-12878. ISSN 0027-8424.
Backert, S. and Fronzes, Remi and Waksman, Gabriel (2008) VirB2 and VirB5 proteins: specialized adhesins in bacterial type-IV secretion systems? Trends in Microbiology 16 (9), pp. 409-413. ISSN 0966-842X.
November 2008
Verger, Denis and Rose, R.J. and Paci, E. and Costakes, G. and Daviter, Tina and Hultgren, S.J. and Remaut, Han and Ashcroft, A.E. and Radford, S.E. and Waksman, Gabriel (2008) Structural determinants of polymerization reactivity of the P pilus Adaptor Subunit PapF. Structure 16 (11), pp. 1724-1731. ISSN 0969-2126.
December 2008
Waksman, Gabriel and Meng, G.Y. and St. Geme, J.W. (2008) Repetitive architecture of the Haemophilus influenzae hia trimeric autotransporter. Journal of Molecular Biology 384 (4), pp. 824-836. ISSN 0022-2836.
2009
Guenou, H. and Nissan, X. and Larcher, F. and Feteira, J. and Lemaître, G. and Saidani, M. and Del Rio, M. and Barrault, C.C. and Bernard, F.-X. and Peschanski, M. and Baldeschi, C. and Waksman, Gabriel (2009) Human embryonic stem-cell derivatives for full reconstruction of the pluristratified epidermis: a preclinical study. The Lancet 374 (9703), pp. 1745-1753. ISSN 0140-6736.
Allen, William J. and Phan, Gilles and Waksman, Gabriel (2009) Structural biology of periplasmic chaperones. In: Eisenberg, D.S. and McPherson, A. (eds.) Advances in Protein Chemistry and Structural Biology. Maryland, U.S.: Academic Press Inc., pp. 51-98. ISBN 9780123748270.
Waksman, Gabriel and Hultgren, S.J. (2009) Structural biology of the chaperone–usher pathway of pilus biogenesis. Nature Reviews Microbiology 7 (11), pp. 765-774. ISSN 1740-1526.
January 2009
Fronzes, Remi and Schafer, Eva and Wang, Luchun and Saibil, Helen R. and Orlova, Elena and Waksman, Gabriel (2009) Structure of a type IV secretion system core complex. Science 323 (5911), pp. 266-268. ISSN 0036-8075.
February 2009
Jakubowski, S.J. and Kerr, J.E. and Garza, I. and Krishnamoorthy, V. and Bayliss, R. and Waksman, Gabriel and Christie, P.J. (2009) Agrobacterium VirB10 domain requirements for type IV secretion and T pilus biogenesis. Molecular Microbiology 71 (3), pp. 779-794. ISSN 0950-382X.
April 2009
Meng, G.Y. and Chandran, Vidya and Remaut, Han and Fronzes, Remi and Waksman, Gabriel (2009) Protein oligomerization in the bacterial outer membrane (Review). Molecular Membrane Biology 26 (3), pp. 136-145. ISSN 0968-7688.
May 2009
Waksman, Gabriel (2009) Going round in circles: the structural biology of type III secretion systems. Nature Structural & Molecular Biology 16 , pp. 459-460. ISSN 1545-9985.
August 2009
Radin, J.N. and Grass, S.A. and Meng, G.Y. and Cotter, S.E. and Waksman, Gabriel and St. Geme, J.W. (2009) Structural basis for the differential binding affinities of the HsfBD1 and HsfBD2 domains in the Haemophilus influenzae Hsf adhesin. Journal of Bacteriology 191 (16), pp. 5068-5075. ISSN 0021-9193.
October 2009
Fronzes, Remi and Christie, P.J. and Waksman, Gabriel (2009) The structural biology of type IV secretion systems. Nature Reviews Microbiology 7 (10), pp. 703-714. ISSN 1740-1526.
November 2009
Durand, E. and Verger, Denis and Rego, A.T. and Chandran, Vidya and Meng, G.Y. and Fronzes, Remi and Waksman, Gabriel (2009) Structural biology of bacterial secretion systems in gram-negative pathogens--potential for new drug targets. Infectious Disorders - Drug Targets 9 (5), pp. 518-847. ISSN 1871-5265.
Hultgren, S.J. and Waksman, Gabriel (2009) Structural biology of the chaperone-usher pathway of pilus biogenesis. Nature Reviews Microbiology 7 , pp. 765-774. ISSN 1740-1526.
Kenjale, R. and Fink, D.L. and Juehne, T. and Ohashi, T. and Erickson, H.P. and Meng, G.Y. and Waksman, Gabriel and St. Geme, J.W. (2009) Structural determinants of autoproteolysis of the Haemophilus influenzae Hap autotransporter. Infection and Immunity 77 (11), pp. 4704-4713. ISSN 0019-9567.
December 2009
Chandran, Vidya and Duquerroy, S. and Cronin, Nora and Navaza, J. and Fronzes, Remi and Waksman, Gabriel (2009) Structure of the outer membrane complex of a type IV secretion system. Nature 462 (7276), pp. 1011-1015. ISSN 0028-0836.
8 January 2010
Rego, A.T. and Fronzes, Remi and Waksman, Gabriel (2010) SnapShot: bacterial appendages I. Cell 140 (1), 162-u163. ISSN 0092-8674.
22 January 2010
Rego, A.T. and Fronzes, Remi and Waksman, Gabriel (2010) SnapShot: bacterial appendages II. Cell 140 (2), p. 294. ISSN 0092-8674.
February 2010
Smith, M.E.B. and Schumacher, F.F. and Ryan, C.P. and Tedaldi, L.M. and Papaioannou, D. and Waksman, Gabriel and Caddick, S. and Baker, J.R. (2010) Protein modification, bioconjugation, and disulfide bridging using Bromomaleimides. Journal of the American Chemical Society 132 (6), pp. 1960-1965. ISSN 0002-7863.
Rego, A.T. and Chandran, Vidya and Waksman, Gabriel (2010) Two-step and one-step secretion mechanisms in gram-negative bacteria: contrasting the type IV secretion system and the chaperone-usher pathway of pilus biogenesis. Biochemical Journal 425 , pp. 475-488. ISSN 0264-6021.
March 2010
Virdee, S. and Macmillan, D. and Waksman, Gabriel (2010) Semisynthetic Src SH2 domains demonstrate altered phosphopeptide specificity induced by incorporation of unnatural lysine derivatives. Chemistry & Biology 17 (3), pp. 274-284. ISSN 1879-1301.
April 2010
Ford, B. and Rego, A.T. and Ragan, T.J. and Pinkner, J.S. and Dodson, K. and Driscoll, P.C. and Hultgren, S.J. and Waksman, Gabriel (2010) Structural homology between the C-Terminal domain of the PapC usher and its plug. Journal of Bacteriology 192 (7), pp. 1824-1831. ISSN 0021-9193.
May 2010
Durand, E. and Oomen, C. and Waksman, Gabriel (2010) Biochemical dissection of the ATPase TraB, the VirB4 homologue of the Escherichia coli pKM101 conjugation machinery. Journal of Bacteriology 192 (9), pp. 2315-2323. ISSN 0021-9193.
12 July 2010
Waksman, Gabriel and Fronzes, Remi (2010) Molecular architecture of bacterial type IV secretion systems. Trends in Biochemical Sciences 35 (12), pp. 691-698. ISSN 0968-0004.
August 2010
Chorell, E. and Pinkner, J.S. and Phan, Gilles and Edvinsson, S. and Buelens, Floris and Remaut, Han and Waksman, Gabriel and Hultgren, S.J. and Almqvist, F. (2010) Design and synthesis of C-2 substituted Thiazolo and Dihydrothiazolo ring-fused 2-Pyridones: Pilicides with increased antivirulence activity. Journal of Medicinal Chemistry 53 (15), pp. 5690-5695. ISSN 0022-2623.
September 2010
Walldén, Karin and Rivera-Calzada, A. and Waksman, Gabriel (2010) Microreview: type IV secretion systems: versatility and diversity in function. Cellular Microbiology 12 (9), pp. 1203-1212. ISSN 1462-5814.
Walldén, Karin and Rivera-Calzada, A. and Waksman, Gabriel (2010) Type IV secretion systems: versatility and diversity in function. Cellular Microbiology 12 (9), pp. 1203-1212. ISSN 1462-5814.
2011
Chudasama, V. and Smith, M.E.B. and Schumacher, F.F. and Papaioannou, D. and Waksman, Gabriel and Baker, J.R. and Caddick, S. (2011) Bromopyridazinedione-mediated protein and peptide bioconjugation. Chemical Communications 47 (31), pp. 8781-8783. ISSN 1359-7345.
Phan, Gilles and Remaut, Han and Wang, T. and Allen, William J. and Pirker, Katharina F. and Lebedev, A. and Henderson, N.S. and Geibel, Sebastien and Volkan, E. and Yan, Jun and Kunze, M.B.A. and Pinkner, J.S. and Ford, B. and Kay, Christopher W.M. and Li, H.L. and Hultgren, S.J. and Thanassi, D.G. and Waksman, Gabriel (2011) Crystal structure of the FimD usher bound to its cognate FimC-FimH substrate. Nature 474 (7349), pp. 49-53. ISSN 0028-0836.
Meng, G. and Spahich, N. and Kenjale, R. and Waksman, Gabriel and St Geme, J.W. (2011) Crystal structure of the haemophilus influenzae hap adhesin reveals an intercellular oligomerization mechanism for bacterial aggregation. The EMBO Journal 30 (18), pp. 3663-3874. ISSN 0261-4189.
Geibel, Sebastien and Waksman, Gabriel (2011) Crystallography and electron microscopy of chaperone/usher pilus systems. Advances In Experimental Medicine & Biology 715 , pp. 159-174. ISSN 0065-2598.
Van Gerven, N. and Waksman, Gabriel and Remaut, H. (2011) Pili and flagella biology, structure, and biotechnological applications. Progress in Molecular Biology and Translational Science 103 , pp. 21-72. ISSN 1877-1173.
Cai, X. and Wang, R. and Filloux, A. and Waksman, Gabriel and Meng, G.Y. (2011) Structural and functional characterization of Pseudomonas aeruginosa CupB chaperones. PLoS One 6 (1), ISSN 1932-6203.
Durand, E. and Waksman, Gabriel and Receveur-Brechot, V. (2011) Structural insights into the membrane-extracted dimeric form of the ATPase TraB from the Escherichia coli pKM101 conjugation system. BMC Structural Biology 11 (4), ISSN 1472-6807.
Ryan, C.P. and Smith, M.E.B. and Schumacher, F.F. and Grohmann, D. and Papaioannou, D. and Waksman, Gabriel and Werner, F. and Baker, J.R. and Caddick, S. (2011) Tunable reagents for multi-functional bioconjugation: reversible or permanent chemical modification of proteins and peptides by control of maleimide hydrolysis. Chemical Communications 47 (19), pp. 5452-5454. ISSN 1359-7345.
March 2011
Lemaître, G. and Stella, A. and Feteira, J. and Baldeschi, C. and Vaigot, P. and Martin, M.T. and Monsarrat, B. and Waksman, Gabriel (2011) CD98hc (SLC3A2) is a key regulator of keratinocyte adhesion. Journal of Dermatological Science 61 (3), pp. 169-179. ISSN 0923-1811.
April 2011
Terradot, L. and Waksman, Gabriel (2011) Architecture of the Helicobacter pylori Cag-type IV secretion system. FEBS Journal 278 (8), pp. 1213-22. ISSN 1742-464X.
May 2011
Banta, L.M. and Kerr, J.E. and Cascales, E. and Giuliano, M.E. and Bailey, M.E. and McKay, C. and Chandran, Vidya and Waksman, Gabriel and Christie, P.J. (2011) An Agrobacterium VirB10 Mutation Conferring a Type IV Secretion System Gating Defect. Journal of Bacteriology 193 (10), pp. 2566-2574. ISSN 0021-9193.
July 2011
Leney, A.C. and Phan, Gilles and Allen, William J. and Verger, Denis and Waksman, Gabriel and Radford, S.E. and Ashcroft, A.E. (2011) Second order rate constants of donor-strand exchange reveal individual amino acid residues important in determining the subunit specificity of Pilus Biogenesis. Journal of The American Society for Mass Spectrometry 22 (7), pp. 1214-1223. ISSN 1044-0305.
19 August 2011
Jiaa, H. and Korolev, S. and Niedziela-Majkaa, A. and Malufa, N.K. and Gaussa, G.H. and Myongf, S. and Hag, T. and Waksman, Gabriel and Lohman, T.M. (2011) Rotations of the 2B sub-domain of E. coli UvrD helicase/translocase coupled to nucleotide and DNA binding. Journal of Molecular Biology 411 (3), pp. 633-648. ISSN 0022-2836.
2012
Volkan, E. and Ford, B.A. and Pinkner, J.S. and Dodson, K.W. and Henderson, N.S. and Thanassi, D.G. and Waksman, Gabriel and Hultgren, S.J. (2012) Domain activities of PapC usher reveal the mechanism of action of an Escherichia coli molecular machine. Proceedings of the National Academy of Sciences of the United States of America 109 (24), pp. 9563-9568. ISSN 0027-8424.
Morrissey, B. and Leney, A.C. and Toste Rego, A. and Phan, G. and Allen, W.J. and Verger, D. and Waksman, Gabriel and Ashcroft, A.E. and Radford, S.E. (2012) The role of chaperone-subunit usher domain interactions in the mechanism of bacterial pilus biogenesis revealed by ESI-MS. Molecular & Cellular Proteomics 11 (7), ISSN 1535-9476.
Ford, B. and Verger, D. and Dodson, K. and Volkan, E. and Kostakioti, M. and Elam, J. and Pinkner, J. and Waksman, Gabriel and Hultgren, S. (2012) The structure of the PapD-PapGII pilin complex reveals an open and flexible P5 pocket. Journal of Bacteriology 194 (23), pp. 6390-6397. ISSN 0021-9193.
April 2012
Busch, Andreas and Waksman, Gabriel (2012) Chaperone-usher pathways: diversity and pilus assembly mechanism. Philosophical Transactions of the Royal Society B: Biological Sciences 367 (1592), pp. 1112-1122. ISSN 0962-8436.
19 April 2012
Waksman, Gabriel (2012) Bacterial secretion comes of age. Philosophical Transactions of the Royal Society B: Biological Sciences 367 (1592), pp. 1014-1015. ISSN 0962-8436.
July 2012
Walldén, Karin and Williams, Robert and Yan, Jun and Lian, Pei W. and Wang, Luchun and Thalassinos, Konstantinos and Orlova, Elena and Waksman, Gabriel (2012) Structure of the VirB4 ATPase, alone and bound to the core complex of a type IV secretion system. Proceedings of the National Academy of Sciences of the United States of America 109 (28), pp. 11348-11353. ISSN 0027-8424.
August 2012
Allen, William J. and Phan, Gilles and Waksman, Gabriel (2012) Pilus biogenesis at the outer membrane of Gram-negative bacterial pathogens. Current Opinion in Structural Biology 22 (4), pp. 500-506. ISSN 0959-440X.
Gonen, T. and Waksman, Gabriel (2012) Recent progress in membrane protein structures and investigation methods. Current Opinion in Structural Biology 22 (4), pp. 467-468. ISSN 0959-440X.
November 2012
Toste-Rêgo, Ana and Johnson, J.G. and Geibel, Sebastien and Enguita, F.J. and Clegg, S. and Waksman, Gabriel (2012) Crystal structure of the MrkD1P receptor binding domain of Klebsiella pneumoniae and identification of the human collagen V binding interface. Molecular Microbiology 86 (4), pp. 882-893. ISSN 0950-382X.
2013
Volkan, E. and Kalas, V. and Pinkner, J.S. and Dodson, K.W. and Henderson, N.S. and Pham, T. and Waksman, Gabriel and Delcour, A.H. and Thanassi, D.G. and Hultgren, S.J. (2013) Molecular basis of usher pore gating in Escherichia coli pilus biogenesis. Proceedings of the National Academy of Sciences of the United States of America 110 (51), pp. 20741-20746. ISSN 0027-8424.
Lithgow, T. and Waksman, Gabriel (2013) Seaside transportation: from structure to function of translocation machines. EMBO reports 14 (7), pp. 585-587. ISSN 1469-221X.
Rothwell, P.J. and Allen, W.J. and Sisamakis, E. and Kalinin, S. and Felekyan, S. and Widengren, J. and Waksman, Gabriel and Seidel, C.A.M. (2013) dNTP-dependent conformational transitions in the fingers subdomain of klentaq1 DNA polymerase: insights into the role of the "nucleotide-binding" state. Journal of Biological Chemistry 288 (19), pp. 13575-13591. ISSN 0021-9258.
March 2013
Allen, William J. and Phan, Gilles and Hultgren, S.J. and Waksman, Gabriel (2013) Dissection of pilus tip assembly by the FimD usher monomer. Journal of Molecular Biology 425 (5), pp. 958-967. ISSN 0022-2836.
April 2013
Geibel, Sebastien and Procko, E. and Hultgren, S.J. and Baker, D. and Waksman, Gabriel (2013) Structural and energetic basis of folded-protein transport by the FimD usher. Nature 496 (7444), pp. 243-246. ISSN 0028-0836.
Lo, A.W. and Van de Water, K. and Gane, P.J. and Chan, A.W. and Steadman, David and Stevens, Kiri and Selwood, D.L. and Waksman, Gabriel and Remaut, H. (2013) Suppression of type 1 pilus assembly in uropathogenic Escherichia coli by chemical inhibition of subunit polymerization. Journal of Antimicrobial Chemotherapy 69 (4), pp. 1017-1026. ISSN 1460-2091.
17 April 2013
Rivera-Calzada, A. and Fronzes, Remi and Savva, Christos G. and Chandran, Vidya and Lian, Pei W. and Laeremans, T. and Pardon, E. and Steyaert, J. and Remaut, Han and Waksman, Gabriel and Orlova, Elena (2013) Structure of a bacterial type IV secretion core complex at subnanometre resolution. The EMBO Journal 32 (8), pp. 1195-1204. ISSN 1460-4189.
26 June 2013
Lillington, James and Waksman, Gabriel (2013) Ordered and ushered; the assembly and translocation of the adhesive Type I and P Pili. Biology 2 (3), pp. 841-860. ISSN 2079-7737.
July 2013
Redzej, Adam and Ilangovan, Aravindan and Lang, S. and Gruber, C.J. and Topf, Maya and Zangger, K. and Zechner, E.L. and Waksman, Gabriel (2013) Structure of a translocation signal domain mediating conjugative transfer by Type IV secretion systems. Molecular Microbiology 89 (2), pp. 324-333. ISSN 0950-382X.
2014
Steadman, David and Lo, A. and Waksman, Gabriel and Remaut, H. (2014) Bacterial surface appendages as targets for novel antibacterial therapeutics. Future Microbiology 9 (7), pp. 887-900. ISSN 1746-0913.
February 2014
Waksman, Gabriel and Orlova, Elena (2014) Structural organisation of the type IV secretion systems. Current Opinion in Microbiology 17 , pp. 24-31. ISSN 1369-5274.
24 April 2014
Low, Harry H. and Gubellini, Francesca and Rivera-Calzada, Angel and Braun, Nathalie and Connery, Sarah and Dujeancourt, A. and Lu, Fang and Redzej, Adam and Fronzes, R. and Orlova, Elena and Waksman, Gabriel (2014) Structure of a type IV secretion system. Nature 508 , pp. 550-553. ISSN 0028-0836.
August 2014
Trokter, Martina and Felisberto-Rodrigues, Catarina and Christie, P.J. and Waksman, Gabriel (2014) Recent advances in the structural and molecular biology of type IV secretion systems. Current Opinion in Structural Biology 27 , pp. 16-23. ISSN 0959-440X.
Geibel, Sebastien and Waksman, Gabriel (2014) The molecular dissection of the Chaperone-Usher Pathway. Biochimica et Biophysica Acta (BBA) - Molecular Cell Research 1843 (8), pp. 1559-1567. ISSN 0167-4889.
September 2014
Lillington, J. and Geibel, Sebastien and Waksman, Gabriel (2014) Biogenesis and adhesion of type 1 and P pili. Biochimica et Biophysica Acta (BBA) - General Subjects 1840 (9), pp. 2783-2793. ISSN 0304-4165.
Gonen, T. and Waksman, Gabriel (2014) Editorial overview - Membranes: recent methods in the study of membrane protein structure. Current Opinion in Structural Biology 27 , iv-v. ISSN 0959-440X.
1 October 2014
Farabella, Irene and Pham, T. and Henderson, N.S. and Geibel, Sebastien and Phan, Gilles and Thanassi, D.G. and Delcour, A.H. and Waksman, Gabriel and Topf, Maya (2014) Allosteric signalling in the outer membrane translocation domain of PapC usher. eLife 3 , ISSN 2050-084X.
15 November 2014
Sayer, J.R. and Walldén, Karin and Pesnot, T. and Campbell, F. and Gane, P.J. and Simone, M. and Koss, H. and Buelens, Floris and Boyle, T.P. and Selwood, D.L. and Waksman, Gabriel and Tabor, A.B. (2014) 2- and 3-substituted imidazo [1,2-a] pyrazines as inhibitors of bacterial type IV secretion. Bioorganic & Medicinal Chemistry 22 (22), pp. 6459-6470. ISSN 0968-0896.
2015
Redzej, Adam and Waksman, Gabriel and Orlova, Elena (2015) Structural studies of T4S systems by electron microscopy. AIMS Biophysics 2 (2), pp. 184-199. ISSN 2377-9098.
March 2015
Busch, A. and Phan, G. and Waksman, Gabriel (2015) Molecular mechanism of bacterial type 1 and P pili assembly. Philosophical Transactions of the Royal Society A: Mathematical, Physical and Engineering Sciences 373 (2037), p. 20130153. ISSN 1364-503X.
May 2015
Ilangovan, Aravindan and Connery, Sarah and Waksman, Gabriel (2015) Structural biology of the Gram-negative bacterial conjugation systems. Trends in Microbiology 23 (5), pp. 301-310. ISSN 0966-842X.
Garnett, J.A. and Muhl, D. and Douse, C.H. and Hui, K. and Busch, Andreas and Omisore, A. and Yang, Y. and Simpson, P. and Marchant, J. and Waksman, Gabriel and Matthews, S. and Filloux, A. (2015) Structure-function analysis reveals that the Pseudomonas aeruginosa Tps4 two-partner secretion system is involved in CupB5 translocation. Protein Science 24 (5), pp. 670-687. ISSN 0961-8368.
15 May 2015
Dias da Costa, Tiago and Felisberto-Rodrigues, Catarina and Meir, A. and Prevost, M.S. and Redzej, Adam and Trokter, Martina and Waksman, Gabriel (2015) Secretion systems in Gram-negative bacteria: structural and mechanistic insights. Nature Reviews Microbiology 13 (6), pp. 343-359. ISSN 1740-1526.
June 2015
Chandran Darbari, V. and Waksman, Gabriel (2015) Structural biology of bacterial Type IV secretion systems. Annual Review of Biochemistry 84 (1), pp. 603-629. ISSN 0066-4154.
July 2015
Kaplan, M. and Cukkemane, A. and van Zundert, G.C.P and Narasimhan, S. and Daniëls, M. and Mance, D. and Waksman, Gabriel and Bonvin, A.M.J.J and Fronzes, R. and Folkers, G.E. and Baldus, M. (2015) Probing a cell-embedded megadalton protein complex by DNP-supported solid-state NMR. Nature Methods 12 (7), pp. 649-652. ISSN 1548-7091.
October 2015
Ruer, S. and Pinotsis, Nikos and Steadman, D. and Waksman, Gabriel and Remaut, H. (2015) Virulence-targeted antibacterials: concept, promise, and susceptibility to resistance mechanisms. Chemical Biology & Drug Design 86 (4), pp. 379-399. ISSN 1747-0277.
14 January 2016
Hospenthal, M.K. and Redzej, A. and Dodson, K. and Ukleja, M. and Frenz, B. and Rodrigues, C. and Hultgren, S.J. and DiMaio, F. and Egelman, E.H. and Waksman, Gabriel (2016) Structure of a Chaperone-Usher Pilus reveals the molecular basis of rod uncoiling. Cell 164 , pp. 269-278. ISSN 0092-8674.
March 2016
Papaioannou, D. and Geibel, S. and Kunze, M.B.A. and Kay, C.W.M. and Waksman, Gabriel (2016) Structural and biophysical investigation of the interaction of a mutant Grb2 SH2 domain (W121G) with its cognate phosphopeptide. Protein Science 25 (3), pp. 627-637. ISSN 0961-8368.
16 May 2016
Stubenrauch, C. and Belousoff, M.J. and Hay, I.D. and Shen, H.-H. and Lillington, James and Tuck, K.L. and Peters, K.M. and Phan, M.-D. and Lo, A.W. and Schembri, M.A. and Strugnell, R.A. and Waksman, Gabriel and Lithgow, T. (2016) Effective assembly of fimbriae in Escherichia coli depends on the translocation assembly module nanomachine. Nature Microbiology 1 (7), p. 16064. ISSN 2058-5276.
8 September 2016
Costa, Tiago and Ilangovan, Aravindan and Ukleja, Marta and Redzej, Adam and Santini, Joanne and Smith, T.K. and Egelman, E.H. and Waksman, Gabriel (2016) Structure of the Bacterial Sex F Pilus reveals an assembly of a Stoichiometric Protein-Phospholipid Complex. Cell 166 (6), 1436-1444.e10. ISSN 0092-8674.
2017
Hospenthal, Manuela K. and Zyla, D. and Costa, Tiago R.D. and Redzej, Adam and Giese, C. and Lillington, James and Glockshuber, R. and Waksman, Gabriel (2017) The Cryoelectron Microscopy structure of the Type 1 Chaperone-Usher Pilus Rod. Structure 25 (12), 1829-1838.e4. ISSN 0969-2126.
Hospenthal, M.K. and Costa, Tiago and Waksman, Gabriel (2017) Pilus biogenesis at the inner and outer membranes of Gram-negative bacteria. Nature Reviews Microbiology 15 , pp. 365-379. ISSN 1740-1526.
Terradot, L. and Bergé, C. and Waksman, Gabriel (2017) Structural and molecular biology of Type IV Secretion Systems. In: Backert, S. and Grohmann, E. (eds.) Type IV Secretion in Gram-Negative and Gram-Positive Bacteria. Current Topics in Microbiology and Immunology 413 413. Springer, pp. 31-60. ISBN 9783319752402.
Hospenthal, M.K. and Costa, Tiago and Waksman, Gabriel (2017) A comprehensive guide to pilus biogenesis in Gram-negative bacteria. Nature Reviews Microbiology 15 (6), pp. 365-379. ISSN 1740-1526.
27 April 2017
Ilangovan, A. and Kay, C.W.M. and Roier, S. and El Mkami, H. and Salvadori, E. and Zechner, E.L. and Zanetti, Giulia and Waksman, Gabriel (2017) Cryo-EM structure of a relaxase reveals the molecular basis of DNA unwinding during bacterial conjugation. Cell 169 (4), 708-721.e12. ISSN 0092-8674.
2 June 2017
Pinotsis, Nikos and Waksman, Gabriel (2017) Structure of the WipA protein reveals a novel tyrosine protein phosphatase effector from Legionella pneumophila. Journal of Biological Chemistry 292 (22), pp. 9240-9251. ISSN 0021-9258.
20 June 2017
Goosens, V.J. and Busch, Andreas and Georgiadou, M. and Castagnini, M. and Forest, K.T. and Waksman, Gabriel and Pelicic, V. (2017) Reconstitution of a minimal machinery capable of assembling periplasmic type IV pili. Proceedings of the National Academy of Sciences of the United States of America 114 (25), E4978-E4986. ISSN 0027-8424.
July 2017
Gordon, J.E. and Costa, Tiago and Patel, R.S. and Gonzalez-Rivera, C. and Sarkar, M.K. and Orlova, Elena and Waksman, Gabriel and Christie, P.J. (2017) Use of chimeric type IV secretion systems to define contributions of outer membrane subassemblies for contact-dependent translocation. Molecular Microbiology 105 (2), pp. 273-293. ISSN 0950-382X.
18 August 2017
Waksman, Gabriel (2017) Structural and molecular biology of a protein-polymerizing nanomachine for pilus biogenesis. Journal of Molecular Biology 429 (17), pp. 2654-2666. ISSN 0022-2836.
25 August 2017
Prevost, Marie S. and Pinotsis, Nikos and Dumoux, Maud and Hayward, Richard D. and Waksman, Gabriel (2017) The Legionella effector WipB is a translocated Ser/Thr phosphatase that targets the host lysosomal nutrient sensing machinery. Scientific Reports 7 (1), ISSN 2045-2322.
18 September 2017
Redzej, Adam and Ukleja, Marta and Connery, Sarah and Trokter, Martina and Felisberto‐Rodrigues, Catarina and Cryar, A. and Thalassinos, Konstantinos and Hayward, Richard D. and Orlova, Elena V. and Waksman, Gabriel (2017) Structure of a VirD4 coupling protein bound to a VirB type IV secretion machinery. The EMBO Journal 36 (19), e201796629. ISSN 0261-4189.
December 2017
Pinotsis, Nikos and Waksman, Gabriel (2017) Crystal structure of the Legionella pneumophila Lpg2936 in complex with the cofactor S-adenosyl-L-methionine reveals novel insights into the mechanism of RsmE family methyltransferases. Protein Science 26 (12), pp. 2381-2391. ISSN 0961-8368.
13 December 2017
Grohmann, E. and Christie, P.J. and Waksman, Gabriel and Backert, S. (2017) Type IV secretion in Gram-negative and Gram-positive bacteria. Molecular Microbiology 107 (4), pp. 455-471. ISSN 0950-382X.
6 February 2018
Meir, A. and Chetrit, D. and Liu, L. and Roy, C. and Waksman, Gabriel (2018) Legionella DotM structure reveals a role in effector recruiting to the Type 4B secretion system. Nature Communications 9 , p. 507. ISSN 2041-1723.
23 February 2018
Trokter, Martina and Waksman, Gabriel (2018) Translocation through the Conjugative Type IV Secretion System requires unfolding of its protein substrate. Journal of Bacteriology 200 (20), ISSN 0021-9193.
Trokter, Martina and Waksman, Gabriel (2018) Translocation through the conjugative Type 4 secretion system requires unfolding of its protein substrate. Journal of Bacteriology 200 (6), JB.00615-17. ISSN 0021-9193.
8 March 2018
Galán, J.E. and Waksman, Gabriel (2018) Protein-injection machines in bacteria. Cell 172 (6), pp. 1306-1318. ISSN 0092-8674.
17 May 2018
Prevost, Marie S. and Waksman, Gabriel (2018) X-ray crystal structures of the Type IVb Secretion System DotB ATPases. Protein Science 27 (8), pp. 1464-1475. ISSN 0961-8368.
22 October 2018
Sgro, G.G. and Costa, Tiago and Cenens, W. and Souza, D.P. and Cassago, A. and Coutinho de Oliveira, L. and Salinas, R.K. and Portugal, R.V. and Farah, C.S. and Waksman, Gabriel (2018) Cryo-EM structure of the bacteria-killing type IV secretion system core complex from Xanthomonas citri. Nature Microbiology 3 (12), pp. 1429-1440. ISSN 2058-5276.
2 January 2019
Waksman, Gabriel (2019) From conjugation to T4S systems in Gram‐negative bacteria: a mechanistic biology perspective. EMBO Reports 20 (2), e47012. ISSN 1469-3178.
25 January 2019
Hospenthal, M.K. and Waksman, Gabriel (2019) The remarkable biomechanical properties of the Type 1 Chaperone-Usher Pilus: a structural and molecular perspective. Microbiology Spectrum 7 (1), ISSN 2165-0497.
8 July 2019
Williams, A.H. and Redzej, Adam and Rolhion, N. and Costa, Tiago R.D. and Rifflet, A. and Waksman, Gabriel and Cossart, P. (2019) The cryo-electron microscopy supramolecular structure of the bacterial stressosome unveils its mechanism of activation. Nature Communications 10 (1), p. 3005. ISSN 2041-1723.
8 June 2020
Meir, A. and Macé, K. and Lukoyanova, N. and Chetrit, D. and Hospenthal, M.K. and Redzej, A. and Roy, C. and Waksman, Gabriel (2020) Mechanism of effector capture and delivery by the type IV secretion system from Legionella pneumophila. Nature Communications 11 (1), ISSN 2041-1723.
February 2022
Mace, Kevin and Meir, A. and Lukoyanova, Natalya and Liu, L. and Chetrit, D. and Hospenthal, M.K. and Roy, C.R. and Waksman, Gabriel (2022) Proteins DotY and DotZ modulate the dynamics and localization of the type IVB coupling complex of Legionella pneumophila. Molecular Microbiology 117 (2), pp. 307-319. ISSN 0950-382X.